Hepatitis

Vopr Kurortol Fizioter Lech Fiz Kult. 2015 Jul-Aug;92(4):25-9.

[The influence of the low-frequency laser radiation on microcirculatory disorders in the patients presenting with chronic viral hepatitis].

[Article in Russian]
Burduli NM, Krifaridi AS, Gutnova SK.
Abstract
AIM:
The objective of the present study was to elucidate the character of microcirculatory disorders in the patients presenting with chronic viral hepatitis and to evaluate the possibilities for the correction of the associated disorders with the use of laser irradiation.
Material and methods. All the patients were divided into three groups. Group 1 was comprised of 30 patients who were treated by means of traditional medicamental therapy alone; they served as controls. Group 2 consisted of 45 patients treated by intravenous laser irradiation in addition to traditional medicamental therapy. The patients of group 3 (n=45) received a course of laser skin treatment. The state of microcirculation was assessed by the laser Doppler flowmetry (LDF) technique with the help of a LAKK-02 apparatus (<<Lazma>> Research and Manufacturing Complex, Moscow, Russia).
RESULTS:
The study has demonstrated heterogeneity of the types of microcirculation with the statistically significant increase in the frequency of its pathological cases. All the patients treated with the use of low-intensity laser therapy exhibited a significant improvement of the blood flow characteristics regardless of the initial hemodynamic type of microcirculation.
CONCLUSION:
It is concluded that the application of laser irradiation as a component of the combined treatment of the patients presenting with chronic viral hepatitis facilitates correction of microcirculatory disorders.
Vopr Kurortol Fizioter Lech Fiz Kult.  2011 Mar-Apr;(2):30-4.

The influence of low-intensity laser radiation on the vascular endothelium function and the cytokine system in patients with chronic viral hepatitis.

[Article in Russian]
Burduli NM, Krifaridi AS.

Abstract

The objective of the present work was to study the influence of low-intensity laser therapy on the cytokine system and the function of vascular endothelium in patients presenting with chronic viral hepatitis. The measurement of blood cytokine levels by an immunoenzyme assay revealed a decrease in the levels of anti-inflammatory IL-1-beta, IL-6, and TNF-alpha and a rise in proinflammatory IL-4 in the treated patients compared with the untreated ones. Medicamental therapy of chronic viral hepatitis did not cause a significant reduction in the plasma nitric oxide level whereas inclusion of low-intense laser irradiation in the combined treatment resulted in its normalization. It is concluded that the use of low-intense laser irradiation as a component of combined therapy of patients presenting with chronic viral hepatitis has marked beneficial effect on the cytokine system. Moreover, various methods of such laser therapy improve the functional activity of vascular endothelium and its NO-producing capacity.

Vopr Kurortol Fizioter Lech Fiz Kult.  2010 Nov-Dec;(6):24-5.

The application of pulsed infrared laser radiation with autoresonant amplification for the treatment of patients with acute viral hepatitis B.

[Article in Russian]

Bagaliev AA.

Abstract

A group of 59 patients presenting with acute viral hepatitis B was available for examination. A single course of pulsed infrared laser irradiation with autoresonant amplification resulted in the improvement of clinical conditions of the patients and normalization of ALAT activity, total and direct bilirubin levels.

Klin Med (Mosk). 2009;87(1):49-52.

Effect of low-intensity laser radiation on the function of vascular endothelium in patients with chronic viral hepatitis.

[Article in Russian]

Burduli NM, Krifaridi AS.

The aim of the study was to measure plasma levels of stable metabolites of nitric oxide, nitrates, and nitrites (NOx) in patients with chronic viral hepatitis and evaluate the possibility of their correction by low-power laser irradiation. NO metabolites (total nitrites and nitrates) were measured colorimetrically from the development of colour in the reaction of nitrite with sulfanilamide diazotization in Griess reagent. Colour intensity was determined with Victor2 enzyme immunoanalyzer, Perkin Elmaer (Finland). The patients were divided into three groups. In group 1 (control, n = 30) they received combined medicamentous therapy, in group 2 (n = 45) medicamentous therapy and a course of intravenous laser therapy, in goup 3 (n = 45) medicamentous therapy and skin laserotherapy. The results indicate that medicamentous treatment of patients with chronic hepatitis does not bring any beneficial changes in plasma NOx whose levels are significantly improved in case of simultaneous laser therapy. It is concluded that different laserotherapeutic modalities have beneficial effect on NO-producing function of endothelium and thereby improve its functional state. Compensation of NO deficit by laser therapy ensures overall protection of the organism against free radicals and decreases severity of oxidative stress.

Ter Arkh. 2001;73(11):26-30.

Comparative efficacy of various methods of laser therapy in patients with acute viral hepatitis B

[Article in Russian]

Makashova VV, Poliakova AM, Maleev VV, Astrina OS, Shatrun TM.

AIM: To study response to laser therapy in different modes and effects on hemocoagulation in patients with acute viral hepatitis B (AVHB).

MATERIAL AND METHODS: Of 173 patients with AVHB, 87 received only basic therapy, 28 patients received placebo (no laser radiation, only signal of the timer) and 58 patients were exposed to laser radiation (32 of them intravenously and 26 supravenously). A course consisted of 10-12 sessions, laser radiation per 1 procedure 300 and 30 mJ, respectively. In addition to routine examinations, hemocoagulation was studied (platelet aggregation and desaggregation, electrocogulogram).

RESULTS: Intoxication, hemorrhagic phenomena, jaundice, infusion therapy, hospital stay were shorter in AVHB patients exposed to laser therapy. Mode of action (intra- or supravenous) was insignificant.

CONCLUSION: Laser therapy normalizes hemostasis and platelet function. Clinical effectiveness of laser was the same in both modes.