Gastrointestinal

Photomed Laser Surg. 2014 Aug;32(8):450-457.

Low-Level Light Therapy Induces Mucosal Healing in a Murine Model of Dextran-Sodium-Sulfate Induced Colitis.

Zigmond E1, Varol C, Kaplan M, Shapira O, Melzer E.

Author information

  • 11 Research Center for Digestive Tract and Liver Diseases, Sourasky Medical Center & the Sackler Faculty of Medicine , Tel-Aviv, Israel .

Abstract

Abstract Objective: The aim of this study was to demonstrate the effect of low-level light therapy (LLLT) in an acute colitis model in mice.

Background data: Low-level light therapy (LLLT) has been shown to be an effective treatment for various inflammatory processes such as oral mucositis and diabetic foot ulcers.

Methods: Colitis was induced by dextran sodium sulfate (DSS) in mice in four blinded controlled studies (validation of model, efficacy study, and two studies for evaluation of optimal dose). LLLT was applied to the colon utilizing a small diameter endoscope with an LED-based light source in several wavelengths (440, 660, and 850 nm at 1 J/cm2) and then 850 nm at several doses (1, 0.5, 0.25, and 0.1 J/cm2). LLLT was initiated 1 day prior to induction of colitis and went on for the 6 day induction period as well as for the following 3-10 days. Dose was controlled by changing exposure time. Disease activity was scored endoscopically and by histopathological assessment.

Results: Statistically significant improvement in disease severity was observed in the treatment groups compared with the control groups. The three wavelengths used demonstrated efficacy, and a clear dose-response curve was observed for one of the wavelengths (850 nm). On day 11, colonoscopic scoring in the sham-treated mice increased from 7.9±1.3 to 12.2±2.2, while activity in all treated groups remained stable.

Conclusions: Photobiostimulation with LLLT has a significant positive effect on disease progression in mice with DSS colitis.

 
Vopr Kurortol Fizioter Lech Fiz Kult.  2012 Nov-Dec;(6):17-20.

The influence of intravenous laser therapy on prostaglandin E2 and F2-alpha dynamics and the state of microcirculation in the patients presenting with gastroesophageal reflux disease.

[Article in Russian]
Burduli NM, Tadtaeva DIa.

Abstract

The objective of the present work was to study the influence of low-frequency laser radiation on the levels of prostaglandins E2 and F2-alpha and characteristics of microcirculation in the patients suffering from gastroesophageal reflux disease (GERD). A total of 112 patients at the age from 19 to 79 years presenting with GERD were examined. 78 of them were given the complete 10-day course of intravenous laser therapy based on a Matriks-VLOK ("Matriks", Russia) therapeutic laser set emitting in the continuous mode at a wavelength of 0.405 mcm with the radiation power 1-11.5 mW at the output of the main lightguide. The characteristics of interest were determined before and after the treatment. It was shown that laser irradiation resulted in the elevation of pro-inflammatory prostaglandin levels and the improvement of parameters of microcirculation.

 
Khirurgiia (Mosk). 2011;(7):53-5.

The use of ozone and low-intensive laser irradiation in complex treatment of complicated duodenal ulcer.

[Article in Russian]
Mamedov RA, Agamirova AN, Dadashev AI, Gasymov ÉM, Kurbanov FS, Dobrovol'ski? SR.

Abstract

The study is based on the examination of 12 patients with perforative duodenal ulcer and 24 patients operated on recurrent bleeding duodenal ulcer. Some component of the immune system, such as T- and B-lymphocytes rates, immunoglobulin rate and macrophagal activity, were decreased prior the beginning of the complex treatment. Normalisation of humoral and cell immunity was registered on 10-12 days after the beginning of the ozone and low-intensive laser irradiation.

Klin Khir. 2010 May;(5):15-7.

Application of low-intensive laser irradiation in the treatment of perforative gastroduodenal ulcers

[Article in Russian]

Makhmudov MG.

Abstract

Comparative analysis of results of surgical treatment, performed for perforative gastroduodenal ulcers in the patients, lacking H. pylori (control group) and owing this etiologic factor (main group), was conducted. Together with other conventional schemes of medicinal treatment in the early postoperative period a low-intensive irradiation of He-Ne laser was applied. Complete eradication of H. pylori was noted in 95.8% patients of the main group. In a late follow-up period (in 1-5 yrs observation terms) the frequency of recurrence, hemorrhage, pyloroduodenal stenosis and other surgical complications, occurring in the main group, was lesser than in a control one.

Eksp Klin Gastroenterol. 2010;(2):32-6.

The laser chromoendoscopy eradication of Helicobacter pylori

 

[Article in Russian]

Pavlov ON, Aleksandrov IuK.

Abstract

35 patients with absence of positive dynamics after course of treatment of diseases associated with Helicobacter pylori infection and without achievement of eradication are surveyed. The original technique of Helicobacter pylori endoscopy eradication with use of the therapeutic laser in length of a wave of 660 nanometers is offered. Carrying out of rate laser chromoendoscopy eradication considerably reduces terms of healing of inflammatory-destructive changes of stomach and duodenum mucous membrane allows achieving of Helicobacter pylori eradication.

Klin Med (Mosk). 2009;87(8):56-61.

Types of microcirculation and laser therapy in chronic pancreatitis

[Article in Russian]

Burduli NM, Gutnova SK.

The aim of the study was to evaluate effect of low-intensity laser therapy (LILT) on systemic circulation in patients with chronic pancreatitis (CP) in the phase of exacerbation. 65 patients aged 36-77 years were divided into study (n = 20) and control (n = 45) groups. In addition, 30 healthy subjects were examined. Patients of the study group received drug therapy combined with intravenous blood or skin laser irradiation. Controls were treated with medicinal preparations alone. CP was diagnosed based on characteristic pain syndrome, compromised secretory function of the pancreas, results of laboratory and instrumental analysis. Microcirculation was studied by laser Doppler flowmetry with a LAKK-02 apparatus (Lazma, Russia). CP patients had heterogeneous microcirculation with a significantly increased frequency of its pathologic types (spastic, hyperemic, spastic-congestive). Major characteristics of microcirculation were significantly different from those in healthy subjects. Combination of drug therapy and LILT substantially improved microcirculation regardless of its hemodynamic type.

Ter Arkh. 2009;81(2):57-61.

Effects of laser reflex therapy on a motor function of the gall bladder and physical properties of bile in patients with chronic acalculous cholecystitis

[Article in Russian]

Burduli NM, Raniuk LG.

AIM: To study effects of laser puncture in combined treatment of chronic non-calculous cholecystitis on motor function of the gallbladder, bile physical characteristics and clinical symptoms. MATERIAL AND METHODS: 73 patients with chronic non-calculous cholecystitis were divided into two groups: 35 patients received standard therapy alone (control group) and 38 patients were exposed to laser puncture as a component of combined treatment. RESULTS: Laser radiation on acupuncture points has a positive therapeutic result, i.e. shorter clinical symptoms, correction of motor function of the gallbladder and bile physical characteristics. CONCLUSION: Laser puncture is an effective method of acalculous cholecystitis treatment and can be included in relevant combined schemes.

Ter Arkh. 2008;80(2):30-3.

Efficacy of different laser treatments in combined therapy of patients with gastroduodenal ulcer

[Article in Russian]

Burduli IM, Gutnova SK.

Abstract

AIM: To investigate efficacy of different methods of low-intensity laser treatment (LILT) in therapy of exacerbated gastroduodenal ulcer.

MATERIAL AND METHODS: A total of 111 gastroduodenal ulcer (GDU) patients were divided into two groups: the study group (81 patients) and control group (30 patients). Patients from the study group received combined treatment with anti-ulcer drugs and LILT performed by three methods: intravenous laser radiation of blood (ILRB), epicutaneous radiation (ER) and combination ILRB+ER. Control patients received medication alone. The efficacy of the treatment was assessed by the time of ulcer defect heeling, duration of hospital stay, clinical symptoms of the disease exacerbation manifesting with three syndromes: pain, dyspepsia, asthenovegetative syndrome.

RESULTS: The shortest heeling of ulcer defect was achieved in the patients treated with ILRB+ER combination: 17.8 +/- 0.8 and 19.3 +/- 3.4 days for gastric and duodenal ulcer, respectively (p < 0.05 and p < 0.01 vs control).

CONCLUSION: Combined treatment of gastric and duodenal ulcer with inclusion of laser radiation (ILRB, ER, ILRB+ER) is effective in therapy of ulcer.

Klin Med (Mosk). 2006;84(7):42-5.

Laser therapy in complex treatment of chronic acalculous cholecystitis

[Article in Russian]

Burduli NM, Raniuk LG.

The effectiveness of various laser techniques in patients with exacerbation of chronic acalculous cholecystitis was studied. The subjects were 62 patients, in whom the diagnosis was made using clinical and instrumental tests. The patients were divided into three groups. Group I received conventional pharmacotherapy; group II received a course of intravenous laser therapy in addition to it; group III received a course of laseropuncture and low-intensive laser irradiation of the hepatic area in addition to pharmacotherapy. The best results according to clinical and instrumental data were achieved in group III. Thus, the study demonstrates advantages provided by laser therapy in complex treatment of exacerbation of chronic acalculous cholecystitis.

Klin Med (Mosk). 2006;84(2):61-4.

The influence of low-intensive laser therapy on the aggregation properties of thrombocytes in patients with peptic ulcer

[Article in Russian]

Burduli NM, Gutnova SK.

The purpose of the study was to evaluate the influence of low-intensive laser therapy (LILT) on the aggregation properties of thrombocytes in patients with exacerbation of peptic ulcer (PU). The subjects, 111 patients aged 18 to 63, were divided into two groups: the main group (n = 81), and the control group (n = 30). In addition there were 15 healthy people who also underwent examination. Patients in the main group received complex treatment with untiulcer drugs and different methods of laser therapy: intravenous laser irradiation of blood, cutaneous irradiation, and a combination of both. The control group was treated with drugs only. The study found various changes in the aggregation properties of thrombocytes in patients with PU exacerbation, which consisted mostly in hyperaggregation. LILT had a normalizing effect on the aggregation properties of thrombocytes in patients of the main group.

Klin Med (Mosk). 2005;83(11):69-71.

Potentialities of alternative non-drug therapy of gastric ulcer

[Article in Russian]

Alebastrov AP, Butov MA.

Abstract

The aim of the study was to evaluate the influence of non-invasive laser therapy on the efficacy of gastric ulcer therapy. The study revealed shortening of the time to ulcer cicatrization in patients who were treated with laser emission of the organospecific iridic zones and immunocompetent body parts in addition to standard drug therapy.

Eksp Klin Gastroenterol. 2004;(4):33-5, 108.

Clinical and immunological aspects of low-intensity laser irradiation inpatients with gastroduodenal ulcers

 

[Article in Russian]

Alebastrov AP, Butov MA, Chumachenko PA.

Abstract

Laser iridotherapy was carried out simultaneously with irradiation of immuno-competent zones on the integument of the human body in patients with stomach and duodenal ulcers. As a result of such treatment, it was discovered that laser therapy has immunomodulating action leading to the reduction of the ulcer cicatrisation period.

Biofizika. 2004 Sep-Oct;49(5):941-7.

Registration of surface fluorescence of endogenous porphyrins during low-level laser therapy of gastric and duodenal ulcers

[Article in Russian]

Klebanov GI, Rogatkin DA, Tereshchenko SG.

Abstract

With the use of the developed opto-fiber spectroscope and gastroscope, the intensity of fluorescence from the ulcer surface into the gastrointestinal tract was measured in the range of 670-690 nm under the He-Ne laser (= 632.8 nm) illumination. Surface fluorescence data were collected with the use of a special diagnostic fiber with a total diameter of about 2 mm, which combines some illuminating and receiving fibers. To do the measurements, the diagnostic fiber was brought into a slight contact with the mucosa surface. The quantitative results were calculated with the use of the special fluorescent contrast coefficient (Kf), which takes into account the backscattered light as well. After the fluorescent diagnostic procedure, the low-level laser therapy was applied to all patients. It was found that: first of all, during the laser medical cure the registered fluorescence for the patients with a good dynamics of treatment had an evident tendency to a decrease, and the coefficient Kf for observed ulcers tended to approach the value obtained from normal mucosa (Kf), which indicates the normalization of the porphyrin content in the tissue. Second, the retrospective analysis of the efficacy of laser therapy versus initial values of Kf showed that, for the patients with the initial values Kf = 0.2, the efficiency of the laser treatment was the highest: the relation between the patients with good treatment results and bad ones was 4:1 (more than 80%). For the initial Kf = 0.2-0.3, this relation was 3:1 but for Kf = 0.4-0.5 it was 2:3. The differences in the efficiency of the low-level laser therapy, except the cases of the cancer in the ulcers, may be due to different content of porphyrin in the tissue: at high concentrations of the photosensitizer in the ulcer, the effect of the overdosing could be realized. In this case, another technology of laser illumination is needed. The results are discussed in terms of the free-radical conception of the stimulating effect of laser radiation.

Eksp Klin Gastroenterol. 2004;(4):29-32, 108.

State of humoral immunity and phagocytic activity of neutrophils in patients with ulcer and effect of low intensity laser therapy

 

[Article in Russian]

Burduli NM, Gutnova SK.

Abstract

The aim of our investigation was to study the influence of low-intensity laser therapy at the immunologic parameters and Helicobacter pylori (HP) microbial contamination in patients with exacerbation of peptic and duodenal ulcer. 100 patients aged 18-65 were examined and divided into 2 groups. The experimental group (75 patients) underwent a complex drug and laser therapy of various therapeutic techniques. The control group (25 patients) underwent only drug therapy. The results of this study show the immunocorrective effect of different methods of low-intensity laser therapy in the exacerbation period and more essential decrease of HP microbial contamination in the experimental group.

Biofizika. 2004 Sep-Oct;49(5):941-7.

Registration of surface fluorescence of endogenous porphyrins during low-level laser therapy of gastric and duodenal ulcers

[Article in Russian]

Klebanov GI, Rogatkin DA, Tereshchenko SG.

Abstract

With the use of the developed opto-fiber spectroscope and gastroscope, the intensity of fluorescence from the ulcer surface into the gastrointestinal tract was measured in the range of 670-690 nm under the He-Ne laser (= 632.8 nm) illumination. Surface fluorescence data were collected with the use of a special diagnostic fiber with a total diameter of about 2 mm, which combines some illuminating and receiving fibers. To do the measurements, the diagnostic fiber was brought into a slight contact with the mucosa surface. The quantitative results were calculated with the use of the special fluorescent contrast coefficient (Kf), which takes into account the backscattered light as well. After the fluorescent diagnostic procedure, the low-level laser therapy was applied to all patients. It was found that: first of all, during the laser medical cure the registered fluorescence for the patients with a good dynamics of treatment had an evident tendency to a decrease, and the coefficient Kf for observed ulcers tended to approach the value obtained from normal mucosa (Kf), which indicates the normalization of the porphyrin content in the tissue. Second, the retrospective analysis of the efficacy of laser therapy versus initial values of Kf showed that, for the patients with the initial values Kf = 0.2, the efficiency of the laser treatment was the highest: the relation between the patients with good treatment results and bad ones was 4:1 (more than 80%). For the initial Kf = 0.2-0.3, this relation was 3:1 but for Kf = 0.4-0.5 it was 2:3. The differences in the efficiency of the low-level laser therapy, except the cases of the cancer in the ulcers, may be due to different content of porphyrin in the tissue: at high concentrations of the photosensitizer in the ulcer, the effect of the overdosing could be realized. In this case, another technology of laser illumination is needed. The results are discussed in terms of the free-radical conception of the stimulating effect of laser radiation.

Vopr Kurortol Fizioter Lech Fiz Kult. 2003 Sep-Oct;(5):26-7.

Effect of impulse infrared laser radiation on bioenergetic metabolism in gastric mucosa in patients with gastroduodenal ulcer

[Article in Russian]

Khamrabaeva FI, Khodzhimatov AA.

Abstract

Gastric mucosa and blood plasm were studied in 82 patients with gastroduodenal ulcer for content of adenylic nucleotides (AMP, ADP and ATP), histamine, amino acids. It was found that the above nucleotides occurred in the examinees in subnormal quantities. The necessary substrates, aspartate in particular, were deficient. This may lead to impairment of biosynthetic processes, to imbalance of defense factors. Photon therapy of gastroduodenal ulcer corrects bioenergetic metabolism in gastric mucosa thus producing a marked therapeutic effect.

Eksperimental’naeiia i klinicheskaeiia gastrocenterologieiia. 2003; (5): 45-50.

 

Laser therapy of duodenal ulcers: effect on indices of microcirculation, cell membrane permeability and homeostasis of trace elements

 

Lazernaia terapiia iazvennoibolezni: vliianie na pokazateli mikrotsirkuliatsii, pronitsaemosti kletochnykh membran i mikroelementnogo gomeostaza.

Amirov N B.

123 patients with duodenal ulcer were examined. Laser therapy (LT) was included in the complex therapy for 89 of the patients. 34 patients underwent only traditional drug therapy and formed a control group. LT was carried out by 2 ways: intracavitary – by ulcer defect irradiation with the light guide through the gastroscope biopsy canal and helium-neon laser (HNL), and non-invasive–through the front abdominal wall in the corresponding areas, which was made by infrared laser (IRL). The comparison of two groups established that by including LT in the complex therapy for DU patients, the dynamics of clinical and laboratorial data is essential better than during traditional drug treatment (TMT). It was established that the inclusion of LT in the duodenal ulcer treatment has a positive impact on the course of the disease. This impact was displayed as faster reverse development of clinical symptoms, positive laboratory and instrumental data dynamics, blood serum microelements content normalization, membrane permeability increase by indicators of Na-Li counter-transport in the erythrocytes membrane and microcirculation improvement, mainly in the intravascular section.

Ter Arkh. 2003;75(9):86-9.  

 

Therapeutic efficiency of a combined use of low-intensity laser radiation and actovegin in gastroduodenal ulcers with inhibited cicatrix formation

[Article in Russian]
 

Vakhrushev IaM, Shkatova EIu.

AIM: To validate use of intravenous laser blood irradiation (ILBI) combined with actovegin administration in indolent gastroduodenal ulcers.

MATERIAL AND METHODS: Modern endoscopic, morphological, device, biochemical techniques and radioimmunoassay were used in examination of 92 patients with indolent gastroduodenal ulcers aged 24 to 69 years. ILBI plus actovegin was given in failure of standard medicinal therapy.

RESULTS: ILBI plus actovegin combination produced marked analgetic, anti-inflammatory and detoxication effects. Favourable trends were observed in the composition of gastric mucus, detoxication, reparative and metabolic processes in the gastroduodenal mucosa, neurohumoral regulation.

CONCLUSION: Combination of ILBI with actovegin proved highly effective in indolent gastroduodenal ulcers.

Vopr Kurortol Fizioter Lech Fiz Kult. 2003 Sep-Oct;(5):26-7.  

Effect of impulse infrared laser radiation on bioenergetic metabolism in gastric mucosa in patients with gastroduodenal ulcer

[Article in Russian]

Khamrabaeva FI, Khodzhimatov AA.

Gastric mucosa and blood plasma were studied in 82 patients with gastroduodenal ulcer for content of adenylic nucleotides (AMP, ADP and ATP), histamine, amino acids. It was found that the above nucleotides occurred in the examinees in subnormal quantities. The necessary substrates, aspartate in particular, were deficient. This may lead to impairment of biosynthetic processes, to imbalance of defense factors. Photon therapy of gastroduodenal ulcer corrects bioenergetic metabolism in gastric mucosa thus producing a marked therapeutic effect.

Eksp Klin Gastroenterol. 2002;(2):58-61, 103.

Changes in local humoral immunity during stomach ulcer healing with laser and drug therapy

[Article in Russian]

Sokolova GN, Tsaregorodtseva TM, Zotina MM.

Central Research Institute of Gastroenterology, Moscow.

Abstract

The increase of the contents of serum IgA, IgG, IgM on the edge of long non-cicatrizing gastric ulcer was determined. At the same time the level of SIgA decreased in comparison with unaltered gastric mucosa. It is shown that the immunoglobulin content in the healed ulcer cicatrice depended on treatment method. The medicamentous therapy was accompanied by lowering of the contents of IgG, IgA, SIgA and by some increase of IgM level. The laser therapy is characterized by lowering of IgA, IgG, IgM level on a background of significant increase of SIgA content. The local humoral immunity after laser therapy was the same as in persons with unaltered gastric mucosa.

Vestn Otorinolaringol. 2002;(5):28-30.

Magneto- laser-phoresis with heparin in the treatment of patients with chronic pharyngitis

[Article in Russian]

Portenko GM, Grafskaia NA.

Abstract

The results of treatment of various forms of chronic pharyngitis by magnetolaserophoresis (MLP) with heparin show that MLP is more effective in hypertrophic chronic pharyngitis. It is emphasized that when planning treatment of chronic pharyngitis one should take into consideration the state of the gastrointestinal tract.

Lik Sprava. 2002;(1):126-9.  

Correction of the gastric and duodenal motility by laser puncture in pancreatobiliary diseases

[Article in Russian]

Gontar AA.

96.7 percent of patients with affections of organs of the pancreatobiliary zone displayed motor function disorders of upper portions of the alimentary canal (AC). A characteristic sign of the pathological process in pancreatobiliary organs is decreased frequency of recordable biopotentials and qualitative changes in electrogastrogrames. Changes in qualitative characteristics of the electrogastrogram are clearly related to increase in the intraduodenal pressure recordable with the aid of the "open catheter" technique. Laseropuncture is an effective supplementary method for correction of motility disorders in the upper portions of AC in those patients presenting with affections of the pancreatobiliary organs.

Lik Sprava. 1998 May;(3):135-7.  

Laser puncture in the combined treatment of stenocardia with concomitant chronic cholecystitis

[Article in Russian]

Akimova LG.

Efficiency was studied of laser acupuncture and quercetin in patients with ischemic heart disease (IHD) with concurrent chronic cholecystitis. Multimodality quantum and antioxidant therapy treatments were found out to have a beneficial effect on the clinical course of both the underlying disease and the concomitant pathologies of the biliary system, making for improvement of hemodynamics and contractile function of the myocardium, returning the hepatic circulation to normal in IHD patients with concomitant chronic cholecystitis that did not respond to conventional therapies.

Klin Khir. 1993;(11):18-20.  

 

The use of laser radiation for correcting cholesterol metabolic disorders in gallstones

[Article in Russian]

Grubnik VV, Zolotareva TA, Kiselev VA.

The authors have demonstrated in the experiment that under the influence of irradiation of the liver by means of a semiconductor laser with a wavelength of 890 nm, pronounced activation of its microsomal system occurs. The data obtained have become a basis for the development and introduction in the clinic in 96 patients of a technique of laser correction of hypercholesterolemia. A good therapeutic effect has been noted in all the patients.

Z Gesamte Inn Med. 1991 Oct;46(15):550-2.

The laser in gastroenterology

[Article in German]

Ell C, Demling L.

Medizinische Klinik, Friedrich-Alexander-Universität Erlangen-Nürnberg.

Abstract

The use of lasers in gastroenterology is an enrichment of the non-invasive therapeutic methods. Prerequisite is their critical use which, in order to be successful, needs a minimum frequency and thus experience. In form of a strictly constructed survey the paper deals with the potential possibilities of laser application and with the alternative approaches being today at our disposal.

Ter Arkh. 1990;62(2):46-8.  

Changes in the intracavitary pressure in the stomach and duodenum with different types of motility

[Article in Russian]

Reshetilov IuI.

As many as 352 patients with different gastroenterological pathology (ulcer disease, chronic gastritis, chronic pancreatitis and cholecystitis) were examined under clinical conditions. Intracavitary pressure and gastric and duodenal motility were recorded on a "Salyut" polygraph with the aid of a tube of original design. It has been discovered that intracavitary pressure in the stomach and duodenum is biphasic in nature and that it may change not only in different diseases but also at different motility types. The changes discovered should be taken into account in administering adequate therapy.

THE USAGE OF INFRA-RED LASER IN THE TREATMENT OF CHOLELITHIASIS

V. Lebedev, V. Erhova

Stavropolskaya Medical Academy, Sanatorium "Metallurg", Essentuky

A series of repeated ultrasonography of gall-bladder in a group of tested patients suffering from cholelithiasis which had undergone different types of physiotherapy revealed a change in bile's echogenic characteristics, the correlation of this index with bile's litho-genesis. The change in bile's density under the influence of intermittent infrared laser (1RL) was studied on these patients. The 1st group (45 patients) took 10 daily procedures of irradiation on the skin projection of the gall-bladder. The treatment was carried out with matrix radiator ML01K of the apparatus "Mustang-021" ("Technics", Russia), 0,89 urn wavelength, frequency 1500-3000 Hz, pulse power 50 W. The 2-nd group (47 per-sons) took 150-200 ml of mineral water "Essentuky-4" (MW) 30 min before meal 3 times a day. All tested patients were subjected to the ultrasonography prior to the treatment's beginning and in 24 hours after the treatment. The obtained result demonstrated a high level in the decrease of bile's density of the tested patients after the influence of 1RL (p<0,05). The 3 rd group (32 persons) united patients (suffering from the same disease) which had took MW and had undergone IRL according to the described methods. Laser influence was applied in 15 min after 2 ND dose of MW. The quantity of compatible pro-cedures was 10. When the treatment of the 3rd group had been completed, ultrasonogra-phy revealed a more high level in the decrease of bile's density (p<0,05). In all groups pa-tients' clinical symptoms quickly improved. 11 patients from the 1 st. and the 3rd groups (8,4 %) suffered from transitory pain in the area of cholecyst during the treatment (be-tween 5-8 courses). The pain disappeared independently, (the treatment hadn't been de-layed) and we explained this additional effect as sand passing and the movement of bili-ary concrement. Under the conditions of balneotherapy, it's worth while the patients suf-fering from cholelitiasis will be treated by IRL according to our methods (MW+IRL) for normalization of gall-bladder function, decrease of bile's lithogenesis and display of cho-langenitis.

DIFFERENT APPROACHES TO LASER THERAPY OF GASTRIC AND DUODENAL ULCERS

N. Popova

Medical Academy, Perm, Russia

Insufficiant effectiveness of modem pharmacological means of duodenal ulcer (DU) treatment, increasing of complications and relapses stimulates a search of new effective methods.

We used different methods of low intensive laser radiation: laser acupuncture (LA), transdermic, infra- and overvascular methods. 280 patients with different forms and courses of ulcer disease (UD) were examined in hospital and polyclinic.

The following examination methods were used: roentgenologicai, fibrogastroscoimages with determination of H pylori, electrogastromiographic, intragastric pH-metry, perioxidate lipoid oxidation, vegetative status determination. We worked out criteria of selection of patients with UD for various treatment methods. In non-complicated and first-revealed forms of DU monotherapy by LA of skin points of activation by helium-neon laser (HNL) ULF-01 "Yagoda" and LG-75 with wave length equal to 0,63 mm was used in compari-son with traditional medicamental therapy (first group). The second group were patients with recurring of DU and accompaning diseases of digestive organs, they were treated by infrared laser "Uzor" and "Mustang" with wave length of 0,89 mm skin acupuncture ac-cording to our method in comparison with traditional medicamental therapy. In the third group of patients with long-term non-scamng DU and double ulcers the treatment was ful-filled by intra- and overvascular irradiation by HNL "Alok-1" and "Mustang".

Good direct and far results were observed. The effectiveness of treatment in the first group was 92%, in the second – 88%, in the third – 76%.

LASER THERAPY IN COMPLEX TREATMENT OF GASTRODUODENAL ULCER

V.V. Osokin, A.A. Martino, V.V. Pavlenko, P.D. Nesterov, V.F. Rozhnev

Moscow Region Center of Laser Surgery, Vidnoye, Russia

The demand of a more effective treatment of gastroduodenal ulcer makes it necessary to combine various techniques. The last few years showed thatlasertherapy was a widely ac-knowledged means for treatment of ulcerative disease of the stomach and duodenum. Starting from 1985 we have treated 359 patients using our own techniques. In the group there were 153 female and 206 male at the age from 19 to 67. All the patients had stom-ach ulcer or duodenum when checked by gastroduodenoscopy, 21 patient had "mirror" ulcer of duodenum. Along with traditional methods of complex treatment we used low-power lasers on arcenide gallium IR-radiation ("Uzor" and "Mustang" apparatus, with the wave length of 0,89 nm, frequency of 80-3000 Hz, and pulse power of 3 to 10 W). The treatment was carried out from the moment the ulcer had been identified and in the case of bleeding-on the day it had been stopped in case of stomach ulcer-after gistology test results. Daily radiation was performed on biologically active points and on the most pain-ful points. The number of sessions was 8 to 12 depending on the size of ulcer. As to 17 patients with nonseaming callous ulcer treating was by means of laser on copper vapour. The average bedding day in the group was 17±2,76 which made 1/3 less compared to that in the control group. So, we can draw a conclusion that complex method in treatment of gastroduodenal ulcer using laser therapy is a promising technique besides it can be used both in hospital and in out patient units.

LASER THERAPY IN COMPLEX TREATMENT OF DUODENAL ULCER

N.A.Krasilnikova, N.I.Polyakova, G.I.Volskaya

Out-Patients Clinic of the Chief Directorate of Home Affairs, St. Petersburg, Russia

The efficiency of laser therapy in complex treatment of duodenal ulcer has been evaluated for 110 patients. Most patients (71,4 percent) were people under 40 years of age with chronic ulcerous process (89,6 percent), pronounced pain, and an ulcerous defect measur-ing 1,0 by 0,7-0,8 cm. A soft infrared laser was used. It was applied in pulsed operation at 90 Hz, 20 mW. The duration of one exposure was 4 minutes. Exposure zones varied every day: projection of the ulcer on the front abdominal wall and the point under xiphoid process of sternum were alternated with paravertebral zones along intercostal areas from ??6 to Th9 symmetrically on both sides. The cource of treatment included 10 daily pro-cedures. The technique was suggested by the Department of Physiotherapy and Balneol-ogy of St. Petersburg Medical Academy of Post-Graduate Education. The treatment effi-ciency was evaluated by means of fibrogastroduodenoscopy. The formation of paunch on the site of ulcer defect as a result of laser therapy was observed for 64 patients (58,2 percent); 18 patients (16,4 percent) showed a decrease of the ulcer defect by 80 percent. Pain was usually eliminated after the third or fourth procedure. The results obtained seem to indicate that the technique employed is quite efficient and can be used in complex treatment of duodenal ulcer.

MAGNETOLASER THERAPY OF ULCER BULBUS DUODENAL DISEASE (ASPECTS OF IMMUNOLOGY0

Nikitin A.V, Lachin V.V, Esaulenko A.E.

Medical Academy, Voronezh, Russia

The patients with ulcer of bulbous duodenal were examined on index of cellular and hu-moral immunity after the treatment with the help of semiconductor laser of near infra-red-spectrum for choosing the right time of setting and the dose of laser therapy as the immu-notherapy. The blood of 20 patients with ulcer bulbous duodenal was analyzed before and after the laser-therapy on the base of threefold therapy (blocs of proton pump + metroni-dazol + amoxycillin).The following indices were determined: the level of T-lymphocytes and their subpopulations, B-lymphocytes, Ig A, G, M and leukocytes, lymphocytes, seg-mental neutrophyles of peripheral blood. The laser therapy was conducted by transcuta-neous method with the help of "Uley-2k" (wavelength – 0,89 nm, pulse regime) with magnetic nozzle MN-1-055 (32 mT). Before the treatment most of the patients had the low indices of leukocytes and lymphocytes, CD-4, B-lymphocytes, Ig A, M, G with in-crease CD-8, T-lymphocytes active forms (CD-4/ CD-8 = 3,75). After two weeks of com-plex treatment with the help of magnetic laser therapy there was a cicatrizing effect of ul-cer defect most of 18 patients (90%). The laboratory results are: indices of leukocytes of blood became normal; lymphocytes and segmental neutrophyles increased with activation their function; T-lymphocytes, CD-4, Ig A, M – increased: CD-8, active forms of T-lymphocytes, B-lymphocytes became normal. Remained the low level of Ig G. So the complex treatment of ulcer of bulbous duodenal disease with the help of magnetolaser therapy brings improved tendency of disease, the fast ulcer cicatrize and immunomodula-tion effect. Therefore it must be applied on early stage of disease.

MODERN APPROACHES TO LASER THERAPY OF GASTRIC AND DUODENAL ULCER

N.I. Popova

Medical Academy, Perm, Russia

Lately various methods of laser therapy of gastric (GU) and duodenal (DU) ulcer such as transendoscoimages, intravascular, transdermic, laser acupuncture (LA) are widely used to-gether with medicaments therapy. At the same time there are no clear criteria of patient's selection for every treatment method. The aim of this study is to examine effectiveness of various methods of laser influence on patients with relapsing form ofGU and DU. 262 pa-tients with different forms and courses of ulcer disease have been observed. The state ofantioxidant and immune systems and vegetative status have been studied by roentge-nological, fibrogastro duodenoscoimages, clectrogastromiographic and intragastric pH – metre methods. In the I group of patients with non-complicated and first revealed forms of DU monotherapy by LA according to our method of skin points activation by helium-neon la-ser (HNL) ULF-01 "Yagoda" and LG-75 with wavelength equal to 0,63 mm, 10 seances. The II group of patients with long-term non-scarring GU and DU have treated by intra-vascular blood irradiation by HNL "ALOK-I" up to 30 min,10 seances together with the use of cholinolytes and antacid's. The III group of patients with recurring DU and pathol-ogy of gastroduodenal tract and cardiovascular system have been treated by infrared laser "UZOR" skin acupuncture to epigastric area and by supravenous acupuncture to ulnar flexion according to our method, 10 seances. Good direct and far results of LA method both in hospital and polyclinic. The effectiveness of treatment in the I group is 92,3%, II-78%, III – 88%.

Complex treatment of non-specific ulcerative colitis with low-level HeNe laser used transanally

Dubinkin V A, Mimrikova E G.

81 patients (average age 42) with non-specific ulcerous colitis were treated with trans-anal HeNe laser. After 10-12 sessions 72% of the patients noted a reduction of pain and the stool became rare. Colonoscopy showed that the mucous membrane regenerated rapidly with an increased vascular picture.