Anti-Aging – Aesthetics

Lasers Med Sci.  2012 Feb 8. [Epub ahead of print]

Biostimulatory effect of low-level laser therapy on keratinocytes in vitro.

Basso FG, Oliveira CF, Kurachi C, Hebling J, Costa CA.

Source

Piracicaba School of Dentistry, UNICAMP – University of Campinas, Piracicaba, SP, 13414-903, Brazil.

Abstract

Epithelial cells play an important role in reparative events. Therefore, therapies that can stimulate the proliferation and metabolism of these cells could accelerate the healing process. To evaluate the effects of low-level laser therapy (LLLT), human keratinocytes were irradiated with an InGaAsP diode laser prototype (LASERTable; 780?±?3 nm; 40 mW) using 0.5, 1.5, 3, 5, and 7 J/cm(2) energy doses. Irradiations were done every 24 h totaling three applications. Evaluation of cell metabolism (MTT assay) showed that LLLT with all energy doses promoted an increase of cell metabolism, being more effective for 0.5, 1.5, and 3 J/cm(2). The highest cell counts (Trypan blue assay) were observed with 0.5, 3, and 5 J/cm(2). No statistically significant difference for total protein (TP) production was observed and cell morphology analysis by scanning electron microscopy revealed that LLLT did not promote morphological alterations on the keratinocytes. Real-time polymerase chain reaction (qPCR) revealed that LLLT also promoted an increase of type I collagen (Col-I) and vascular endothelial growth factor (VEGF) gene expression, especially for 1.5 J/cm(2), but no change on fibroblast growth factor-2 (FGF-2) expression was observed. LLLT at energy doses ranging from 0.5 to 3 J/cm(2) promoted the most significant biostimulatory effects on cultured keratinocytes.

J Invest Dermatol. 2009 Dec;129(12):2751-9. Epub 2009 Jul 9.

Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study.

Barolet D<>, Roberge CJ<>, Auger FA<>, Boucher A<>, Germain L<>.

RoseLab Skin Optics Laboratory, 3333 Graham Blvd., Suite 206, Montreal, Quebec H3R 3L5, Canada. daniel.barolet@mcgill.ca

It has been reported that skin aging is associated with a downregulation in collagen synthesis and an elevation in matrix metalloproteinase (MMP) expression. This study investigated the potential of light-emitting diode (LED) treatments with a 660 nm sequentially pulsed illumination formula in the photobiomodulation of these molecules. Histological and biochemical changes were first evaluated in a tissue-engineered Human Reconstructed Skin (HRS) model after 11 sham or LED light treatments. LED effects were then assessed in aged/photoaged individuals in a split-face single-blinded study. Results yielded a mean percent difference between LED-treated and non-LED-treated HRS of 31% in levels of type-1 procollagen and of -18% in MMP-1. No histological changes were observed. Furthermore, profilometry quantification revealed that more than 90% of individuals showed a reduction in rhytid depth and surface roughness, and, via a blinded clinical assessment, that 87% experienced a reduction in the Fitzpatrick wrinkling severity score after 12 LED treatments. No adverse events or downtime were reported. Our study showed that LED therapy reversed collagen downregulation and MMP-1 upregulation. This could explain the improvements in skin appearance observed in LED-treated individuals. These findings suggest that LED at 660 nm is a safe and effective collagen-enhancement strategy.

Photomed Laser Surg. 2009 Dec;27(6):969-71.

Green tea and red light–a powerful duo in skin rejuvenation.

Sommer AP<>, Zhu D<>.

Institute of Micro and Nanomaterials, University of Ulm, Ulm, Germany. andrei.sommer@uni-ulm.de

OBJECTIVE: Juvenile skin has been the subject of intense research efforts since ancient times. This article reports on synergistic complementarities in the biological actions of green tea and red light, which inspired the design of a green tea-assisted facial rejuvenation program. BACKGROUND DATA: The approach is based on previous laboratory experiments providing insight into a mechanism by which visible light interacts with cells and their microenvironment. METHODS: After 2 months of extreme oxidative stress, green tea-filled cotton pads were placed once per day for 20 minutes onto the skin before treatment with an array of light-emitting diodes (central wavelength 670 nm, dermal dose 4 J/cm2). RESULTS: Rejuvenated skin, reduced wrinkle levels, and juvenile complexion, previously realized in 10 months of light treatment alone were realized in 1 month. CONCLUSION: The accelerated skin rejuvenation based on the interplay of the physicochemical and biological effects of light with the reactive oxygen species scavenging capacity of green tea extends the action spectrum of phototherapy. The duo opens the gate to a multitude of possible biomedical light applications and cosmetic formulas, including reversal of topical deterioration related to excess reactive oxygen species, such as graying of hair.

Hautarzt. 2009 Apr;60(4):310-7.

UV, visible and infrared light. Which wavelengths produce oxidative stress in human skin?

[Article in German]

Zastrow L<>, Groth N<>, Klein F<>, Kockott D<>, Lademann J<>, Ferrero L<>.

Coty/Lancaster SAM, International R&D Center, 2 rue de la Lüjernetta, 98000 Monaco, Monaco. leonhard_zastrow@cotyinc.com

Experimental evidence suggests that the creation of free radicals–mainly reactive oxygen species (ROS)–is the common photobiological answer to the skin-sunlight interaction. The free radical action spectrum (wavelength dependency) for ultraviolet and visible light (280-700 nm) has been determined by quantitative ESR spectroscopy. Visible light produces around 50% of the total oxidative stress caused by sunlight. Reactive species like *O(-)(2), *OH and *CHR are generated by visible light. The amount of ROS correlates with the visible light intensity (illuminance). We demonstrated the creation of excess free radicals by near-infrared light (NIR, 700-1600 nm). Free radical generation does not depend exclusively on the NIR irradiance, but also on the NIR initiated skin temperature increase. The temperature dependence follows the physiological fever curve. Our results indicate that the complex biological system skin creates the same type of free radicals over the entire active solar spectrum. This general response will make it possible to define the beneficial or deleterious action of sunlight on human skin by introduction of a free radical threshold value.

J Eval Clin Pract. 2009 Apr;15(2):292-8.

Mirror, mirror on the wall: placebo effects that exist only in the eye of the beholder.

Kelley JM<>, Boulos PR<>, Rubin PA<>, Kaptchuk TJ<>.

Department of Psychology, Endicott College and Harvard Medical School, Beverly, MA, USA.

Rationale The extent to which placebo effects can be driven exclusively by subjective impressions of improvement in the absence of any independent corroboration is unclear. Methods Thirty-six self-referred patients were treated with a light therapy device intended to rejuvenate facial skin. At each of eight weekly treatments, participants’ facial skin was exposed for 40 seconds to pulses of multispectral LED-generated light in the range of 588 nm wavelength at 0.1 J cm(-2). Outcomes were assessed by participants as well as by the treating doctor and by blinded, expert raters. Results Patients reported robust and statistically significant improvements in seven facial features at the conclusion of the 8-week treatment regimen as well as at 1-month follow-up (for all comparisons, P </= 0.003, median d = 1.14). In sharp contrast, both the treating doctor and blinded, expert raters were unable to detect any improvement whatsoever (for all comparisons, P > 0.05). Moreover, effect sizes were close to zero and in the opposite direction from improvement (median d = -0.06 for doctor ratings; and for observer ratings, there was only a 46% success rate at identifying post-treatment as compared with pre-treatment photographs). Conclusion The robust placebo responses documented in this trial were confined to the subjective impressions of the patients. Neither the treating doctor nor blinded, expert raters could detect any improvement. Thus, patients can perceive improvement in medical interventions in the absence of any independent corroboration that improvement has occurred. This result is used a heuristic to more clearly define the components of the placebo response.

Indian J Dermatol Venereol Leprol. 2009 Mar-Apr;75(2):119-25.

Targeted phototherapy.

Mysore V<>.

Centre for Advanced Dermatology, Bangalore, India. mysorevenkat@hotmail.com<>

Phototherapy is one of the most important therapeutic modalities in dermatology. This field has seen several major advances in the recent years, the most recent being targeted phototherapy. Targeted phototherapy, which includes laser and nonlaser technologies, delivers light/laser in the ultraviolet spectrum, of specific wavelength, specifically targeted at the affected skin and thereby avoids many of the side effects of conventional phototherapy. The treatment has been claimed to be effective, quick, and needing fewer treatment sessions. The article reviews this new mode of phototherapy.

J Drugs Dermatol. 2009 Mar;8(3):221-6.

Assessment of the mobile delivery of infrared light (1100-1800 nm) for the treatment of facial and neck skin laxity.

Alexiades-Armenakas M<>.

Yale University School of Medicine, USA. dralexiades@nyderm.org

BACKGROUND: Previous studies have shown that although infrared light and radiofrequency delivered by stationary application is safe and effective for the treatment of rhytides, a mobile delivery of radiofrequency energy can render the treatment as painless. In addition, few studies have defined and assessed efficacy of these infrared treatments in treating laxity by quantitative grading. OBJECTIVE: This prospective study assesses the safety, efficacy, and pain profile of the application of infrared light with a mobile delivery method for the treatment of facial and neck skin laxity as assessed by a tested, quantitative grading scale. METHODS: In this study, 22 female subjects (aged 40-75 years; Caucasian and Asian ancestry) with a clinically observable excess of laxity (minimum grade 2 out of 4) on the face received 1 to 3 treatments with incoherent infrared (1100-1800 nm) light at 2-week to 4-week intervals. Each light pulse was administered in a mobile continuous fashion within a localized area measuring approximately 1 handpiece tip-width laterally and vertically. A series of 4 to 5 pulses were administered across small grid areas, followed by 6 to 8 passes to each grid area, totaling approximately 300 to 450 pulses per treatment. Each mobile pulse was delivered at fluences of 45 to 46 J/cm2 to the face, 45 J/cm2 to the mandible, and 44 J/cm2 to the neck. Clinical results were evaluated employing a comprehensive 4-point grading scale from photographs at baseline, and the 1-month and 3-month follow-up visits after the final treatment. Pain ratings were evaluated by visual analog scale (VAS) gradings and patient questionnaire immediately following treatment. RESULTS: All subjects completed and responded to treatment. The mean treatment number was 2.1 (+/- 0.9) and the mean follow-up interval was 1.9 (+/- 1) months. The quantitative evaluations demonstrated: a mean baseline laxity grade of 2.9 +/- 0.5 and mean posttreatment laxity grade of 2.5 +/- 0.6; and a mean difference in prelaxity grades versus postlaxity grades of 0.4 +/- 0.3 (95% CI; 0.2540-0.5415). The data demonstrated a statistically significant difference between before and after measurements (P<.0001) and a mean percent improvement in laxity grading scores of 14.1 +/- 11.3%. The treatment discomfort was rated as a mean of 0.7 (+/- 0.6) on a VAS grading scale (0 to 10). By patient questionnaire, sensation during the treatment was rated as painless by 100% of patients and rare (<5) transient moments of heat-related pain sensation were reported by 18% of patients. None of patients reported the procedure as painful or as sensing frequent (>5) or persistent heat-related pain sensation during the treatment. Other side effects included minimal erythema which resolved within 1 to 3 hours. No crusting, dyspigmentation, or scarring was observed. CONCLUSION: This prospective clinical study with quantitative grading of laxity and VAS pain scores demonstrated that mobile delivery of infrared light appears to be safe, clinically effective, and painless in reducing facial and neck laxity. The mobile infrared light delivery allowed for delivery of approximately 30% higher fluence dosages and increased passes to each pulse area. The clinically observable and quantified decreases in skin laxity following treatment were statistically significant.

Dermatol Surg. 2009 Feb;35(2):229-39.

In the eye of the beholder–skin rejuvenation using a light-emitting diode photomodulation device.

Boulos PR<>, Kelley JM<>, Falcão MF<>, Tremblay JF<>, Davis RB<>, Hatton MP<>, Rubin PA<>.

Department of Ophthalmology, Oculofacial Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.

BACKGROUND: A light-emitting diode (LED) photomodulation system can produce pulses of amber light expected to induce structural skin changes and reverse the effects of photoaging. OBJECTIVE: To reproduce the encouraging results already published. METHODS AND MATERIALS: Facial skin was exposed to pulses of 588+/-10-nm-wavelength light from a photomodulation device for 40 seconds once a week for 8 weeks. Photographs, clinical assessment, and a subjective questionnaire were taken at baseline, at the last follow-up, and 1 month after that. Thirty-six patients’ pre- and post-treatment photos were arbitrarily scrambled, and 30 independent blinded observers were asked to pick the post-treatment photo. Two time-point comparisons were evaluated. RESULTS: For every facial characteristic studied and for both time-point comparisons, patients reported highly statistically significant improvements. In extremely sharp contrast, neither the physician’s assessment nor the independent observers’ evaluation indicated any improvement. CONCLUSION: Although subjective findings are comparable between studies, we were unable to reproduce the objective results of efficacy previously reported. Patients genuinely believed that several of their facial features had improved, even though there was no detectable objective change. Our data therefore suggest that the LED photomodulation treatment from the device tested is a placebo.

Semin Cutan Med Surg. 2008 Dec;27(4):301-8.

 

Future considerations in cutaneous photomedicine.

 

Winstanley DA<>, Uebelhoer NS<>.

Department of Dermatology, Naval Medical Center San Diego, 34520 Bob Wilson Drive, San Diego, CA 92134, USA. douglas.winstanley@med.navy.mil<>

Laser and light technology and their use in dermatology are rapidly advancing. Radiofrequency devices have recently integrated lasers to augment the beneficial effects of both while minimizing potential complications of each. Laser-assisted liposuction is becoming more commonplace, and new investigations into the noninvasive selective destruction of fat with lasers have been undertaken. A better understanding of photobiology has generated renewed interest in the effects of low-level laser therapy on skin and wound healing. Lasers also are being used in novel ways for the purposes of in vivo diagnosis, producing some incredible imaging that may prove useful in the early diagnosis and evaluation of cutaneous disease. Finally, more recent work in the field of photochemical tissue bonding may be bringing us closer to sutureless and scarless surgery. Although not an exhaustive review, this article explores some recent advances in laser and light technologies for dermatologic applications and diagnosis.

Semin Cutan Med Surg. 2008 Dec;27(4):227-38.

Light-emitting diodes (LEDs) in dermatology.

Barolet D<>.

RoseLab Skin Optics Research Laboratory, 3333 Graham Blvd., Montreal, Quebec, Canada. daniel.barolet@mcgill.ca

Light-emitting diode photobiomodulation is the newest category of nonthermal light therapies to find its way to the dermatologic armamentarium. In this article, we briefly review the literature on the development of this technology, its evolution within esthetic and medical dermatology, and provide practical and technical considerations for use in various conditions. This article also focuses on the specific cell-signaling pathways involved and how the mechanisms at play can be put to use to treat a variety of cutaneous problems as a stand-alone application and/or complementary treatment modality or as one of the best photodynamic therapy light source.

J Cosmet Dermatol. 2008 Dec;7(4):263-7.

A study to determine the efficacy of a novel handheld light-emitting diode device in the treatment of photoaged skin.

Sadick NS<>.

Department of Dermatology, Weill Medical College of Cornell University, New York, NY 10021, USA. nssderm@sadickdermatology.com

The use of visible or near-infrared spectral light alone for the purpose of skin rejuvenation has been previously reported in the literature. These devices use large arrays of diodes to deliver light to the skin. In this study, a novel method of light-emitting diode (LED) photo rejuvenation incorporating a combination of these wavelengths delivered from a small handheld unit is proposed. Twenty-two subjects with facial rhytides received eight light therapy treatments over a course of 4 weeks, using the Omnilux handheld LED system. Assessment of global skin grading was evaluated at weeks 6, 9, and 12 by a dermatologist. Additional outcome measures included assessments of clinical photography and patient satisfaction scores. Seventy-four percent of the subjects reported a visible improvement in fine lines and wrinkles at 8 weeks posttreatment. Combination red and near-infrared LED therapy delivered from a small portable handheld unit represents an effective and acceptable method of photo rejuvenation. Further studies to optimize the parameters of treatment are required.

Dermatol Surg. 2008 Nov;34(11):1459-64. Epub 2008 Sep 15.

Application of a new intense pulsed light device in the treatment of photoaging skin in Asian patients.

Li YH<>, Wu Y<>, Chen JZ<>, Gao XH<>, Liu M<>, Shu CM<>, Dong GH<>, Chen HD<>.

Department of Dermatology, No 1 Hospital of China Medical University, Shenyang, PR China.

BACKGROUND: Intense pulsed light (IPL) technology has long been used in the treatment of photoaging skin. OBJECTIVE: To evaluate the efficacy and safety of a new IPL device in the treatment of photoaging skin in Asian patients. METHODS: One hundred fifty-two Chinese women with photoaging skin were enrolled in this open-labeled study. Subjects received four IPL treatments at 3- to 4-week intervals. Changes of photoaging were evaluated using a global evaluation, an overall self-assessment, a Mexameter, and a Corneometer. RESULTS: One hundred thirty-nine of 152 patients (91.44%) experienced a score decrease of 3 or 2 grades, according to the dermatologist. One hundred thirty-six of 152 patients (89.47%) rated their overall improvement as excellent or good. The mean skin melanin index (MI) and erythema index values deceased with each session. MI on forehead and EI on cheilion decreased most significantly. Adverse effects were limited to mild pain and transient erythema. CONCLUSION: IPL treatment is a safe and effective method for photoaging skin in Asian patients. Adverse effects were minimal and acceptable.

Photomed Laser Surg. 2008 Oct;26(5):433-42.

Role of nitric oxide in the visible light-induced rapid increase of human skin microcirculation at the local and systemic level: I. diabetic patients.

Samoilova KA<>, Zhevago NA<>, Menshutina MA<>, Grigorieva NB<>.

Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia. samoilova3@yandex.ru

OBJECTIVE: This study aimed to reveal the effects of polychromatic visible (pVIS) or pVIS + near IR (nIR) light similar to some components of solar light on skin microcirculation and microvascular response to the vasodilatators acetylcholine (ACh) and nitroglycerine (NG), in the extremities of patients with diabetic microangiopathy. BACKGROUND DATA: The mechanisms behind light-induced increases in microcirculation as well as extracellular effects of terrestrial pVIS and pVIS + nIR light remain unknown. MATERIALS AND METHODS: In 24 subjects with type 2 diabetes mellitus local microcirculation was measured in the skin of the foot before and after exposure to both types of light. In another 26 patients systemic microcirculation was studied in the back of the hand before and after exposure of the lumbar-sacral area to light energy. Two different types of light therapy were performed by using two devises: Q-light, which delivers pVIP (385-750 nm) and pVIS nIR light (385-1700 nm) with a power density of 40 mW/cm2, which is similar to summer sunlight at noon in Central Europe. RESULTS: At 2 min after irradiation (12 J/cm2) of the forefoot with pVIS or pVIS + nIR light, a rise in local blood flow volume (Qas) was observed, on average by 39% and 31%, respectively. The maximal effect (+41-47%) had developed in all patients at 30 min, and it then decreased and disappeared completely 24 h post-irradiation. We obtained similar results after irradiation of the sacral area in Qas of the skin of the hand. Both types of microcirculation also increased following a second exposure to the light sources. Enhancement of microcirculation was accompanied by a decrease in the microvascular response to ACh and NG solutions administered intracutaneously by iontophoresis. CONCLUSION: Both types of irradiation stimulated microcirculation at the local and systemic levels through a mechanism of enhancement of endothelium-dependent and endothelium-independent vasodilation, in which nitric oxide plays

Lasers Surg Med. 2008 Feb;40(2):106-12.

LED photoprevention: reduced MED response following multiple LED exposures.

Barolet D<>, Boucher A<>.

RoseLab, Skin Optics Laboratory, Montreal, Quebec, Canada. dbarolet@opusmed.com

BACKGROUND AND OBJECTIVES: As photoprotection with traditional sunscreen presents some limitations, the use of non-traditional treatments to increase skin resistance to ultraviolet (UV) induced damage would prove particularly appealing. The purpose of this pilot study was to test the potential of non-thermal pulsed light-emitting diode (LED) treatments (660 nm) prior to UV exposure in the induction of a state of cellular resistance against UV-induced erythema. STUDY

DESIGN/MATERIALS AND METHODS: Thirteen healthy subjects and two patients with polymorphous light eruption (PLE) were exposed to 5, 6, or 10 LED treatments (660 nm) on an EXPERIMENTAL anterior thigh region. Individual baseline minimal erythema doses (MED) were then determined. UV radiation was thereafter performed on the LED EXPERIMENTAL and CONTROL anterior thigh areas. Finally, 24 hours post-UV irradiation, LED pre-treated MED responses were compared to the non-treated sites.

RESULTS: Reduction of erythema was considered significant when erythema was reduced by >50% on the LED-treated side as opposed to CONTROL side. A significant LED treatment reduction in UV-B induced erythema reaction was observed in at least one occasion in 85% of subjects, including patients suffering from PLE. Moreover, there was evidence of a dose-related pattern in results. Finally, a sun protection factor SPF-15-like effect and a reduction in post-inflammatory hyperpigmentation were observed on the LED pre-treated side.

CONCLUSIONS: Results suggest that LED based therapy prior to UV exposure provided significant protection against UV-B induced erythema. The induction of cellular resistance to UV insults may possibly be explained by the induction of a state a natural resistance to the skin via specific cell signaling pathways and without the drawbacks and limitations of traditional sunscreens. These results represent an encouraging step towards expanding the potential applications of LED therapy and could be useful in the treatment of patients with anomalous reactions to sunlight.

Dermatol Surg. 2004 Jun;30(6):872-9; discussion 879-80.

Treatment of neck lines and forehead rhytids with a nonablative 1540-nm Er:glass laser: a controlled clinical study combined with the measurement of the thickness and the mechanical properties of the skin.

 

Dahan S<>, Lagarde JM<>, Turlier V<>, Courrech L<>, Mordon S<>.

Dermatology and Laser Center, Clinique St Jean du Languedoc, Toulouse, France.

BACKGROUND: Nonablative remodeling has been recently proposed as a new, no-down-time, anti-aging treatment. Objective. The objective was to evaluate the efficacy and safety of nonablative skin remodeling with a 1540-nm Er:Glass laser on neck lines and forehead rhytids. METHODS: Twenty female patients (mean age 45 years) were enrolled. Skin thickness and mechanical properties were measured before the first treatment, 1 month after the third treatment, 1 month after the fifth treatment, and 3 months after the fifth treatment. RESULTS: All patients reported an improvement in both skin tone and texture. Using ultrasound imaging, dermal thickness of neck and forehead increased, respectively, by 70+/-13 microm (p<0.001) and 110+/-19 microm (p<0.003). A dramatic increase of initial stress of the forehead skin (firmness) was obtained, from 7.62+/-3.68 before treatment to 16.68+/-7.44 3 months after the fifth treatment (p<0.0002). No immediate or late adverse effects were noted throughout the treatment regimen. CONCLUSION: This study demonstrates that irradiation with a 1540-nm Er:Glass laser emitting in a pulsed mode and coupled with an efficient contact cooling system increases dermal thickness and firmness, leading to a clinical improvement of neck lines and forehead rhydits.

J Cosmet Laser Ther. 2007 Dec;9(4):226-30

A self-reported clinical trial investigates the efficacy of 1072 nm light as an anti-ageing agent.

Stirling RJ<>, Haslam JD<>.

Department of Ophthalmology, Darlington Memorial Hospital, County Durham, UK.

BACKGROUND: Previous laboratory research has shown that human lymphocytes pre-irradiated with 1072 nm light are afforded some protection against subsequent ultraviolet light toxicity.

OBJECTIVE: To investigate the possibility that 1072 nm light can prevent or reverse skin ageing which itself is known to be accelerated by ultraviolet light.

METHODS: A randomized, prospective, double-blind, placebo-controlled, self-reporting study was performed to assess the effect of one daily treatment episode for a period of between 6 and 8 weeks on wrinkles and fine lines around the eyes as well as the appearance of bags under the eyes.

RESULTS: Between 52% and 57% of volunteers were able to accurately identify an improvement in the fine lines and wrinkles of the treated areas of skin. Fewer volunteers, between 37% and 46%, observed an improvement in the bags under the treated eye or eyes, albeit with an emphatic statistical significance.

CONCLUSION: Regular application of a non-thermal quantity of 1072nm light around the eyes demonstrated efficacy as an anti-ageing agent.

Clin Plast Surg. 2008 Oct;35(4):553-66, vi.

Pushing the clock back 15 to 20 years with facial rejuvenation.

Connell BF<>.

University of California, Irvine, College of Medicine, Irvine, CA, USA. drbconnell@aol.com

The goal of rejuvenation is to restore the good looks present 15 to 18 years before without having signs of surgical improvement. Patients should look like themselves at a younger age with specific improvement not present when younger, such as nose or neck contour.

Lasers Surg Med. 2008 Sep;40(7):454-60.

Low density, non-ablative fractional CO2 laser rejuvenation.

Christiansen K<>, Bjerring P<>.

Molholm Research, 7100 Vejle, Denmark. dan-medico@mail.dk

BACKGROUND AND OBJECTIVES: Fractional skin rejuvenation has gained increased interest since its introduction in 2003. Both non-ablative and ablative lasers as well as different treatment techniques have been devised. Recent clinical studies indicate that a paradigm of low spot density combined with high fluences tend to produce better clinical results and less risk of post-inflammatory hyperpigmentation in darker skin types. The present study is focused on investigations of the clinical outcome by non-ablative fractional CO(2) treatments with a single pass with low spot density.

METHODS AND MATERIALS: A CO(2) laser was equipped with a scanner enabling it to perform fractional treatments with 36, 64 or 100 microthermal zones (MTZ)/cm(2). Twelve patients participated in the study. The perioral area was treated three times with 1-month intervals using a spot density of 64 MTZ/cm(2), a spot diameter of 0.5 mm, a micro-beam energy of 36-60 mJ, and a pulse duration of 3-5 milliseconds. Follow-up was performed 3 months after the last treatment.

RESULTS: At the 3-month follow-up 72.7% of the volunteers had obtained improvement in ultrasonographically determined dermal density, and the average improvement was 40.2% (SD: 48.0%). This improvement was statistically significant (P<0.006). Eighty percent of the volunteers rated the reduction in visible perioral wrinkles to be fair, good or excellent. For reduction of irregular pigmentation, fair, good or excellent clearance was reported by 62.5% of the volunteers.

CONCLUSIONS: The present study demonstrates subjective improvements in wrinkles, skin texture and mottled pigmentation as well as statistically significant objectively measured improvements in ultrasonographical dermal density after three non-ablative fractional CO(2) laser treatments.

Lasers Med Sci. 2008 Apr;23(2):149-54. Epub 2007 May 10.

“Multi Light and Drugs”: a new technique to treat face photoaging. Comparative study with photorejuvenation.

Mezzana P<>.

Laser Unit, GeSer SrL, Via Merulana 61/A, 00185, Rome, Italy. pmezzana@yahoo.it

Nonablative skin rejuvenation using laser, intense pulsed lights (IPLs), or radiofrequency techniques are becoming increasingly popular. In this paper, a novel protocol that integrates IPL sessions, low intense light and vitamin C, low-weight hyaluronic acid, betaglucan dermal injection versus IPL photorejuvenation as monotherapy is compared. A group of 100 patients, all women, with ages ranging from 35 to 65 years old (median age 56.3) with different degrees of photodamage was considered. A blinded control study was done. The patients were divided not randomly into two groups. These groups are similar for ages, skin types, and degrees of photoaging distribution. A first group of 40 patients had monotherapy consisting of seven sessions of IPL only. A second group of 60 patients had triple therapy consisting of seven sessions of IPL as well as nine sessions of low intense diode light and also biostimulation by drugs. Considering only the improvement in hyperpigmentations and teleangectasias, the monotherapy and the triple therapy show good results with no significant statistical difference between the two groups. Considering the improvement in skin texture and firmness in the group treated only with monotherapy, 30% (12 patients) had positive results, and 70% (28 patients) had poor results. In the group treated with triple therapy, 70% (42 patients) had positive results, and 30% (18 patients) had poor results, with the main differences in skin silicone negative imprints. On the basis of the data presented, the new technique of IPL, low intensity diode light, and multidrugs biostimulation seems to be a safe and effective method for skin rejuvenation and upgrades the effects of IPL in the fibroblasts’ stimulation.

J Drugs Dermatol. 2008 Mar;7(3):273-9.

Skin rejuvenation in Asian skin: the analysis of clinical effects and basic mechanisms of intense pulsed light.

Feng Y<>, Zhao J<>, Gold MH<>.

Department of Dermatology, Beijing Friendship Hospital affiliated with the Capital University of Medical Sciences, Beijing, China.

BACKGROUND: Skin aging consists of photoaging and intrinsic aging. It is characterized clinically not only by rhytides, but also by pigmentary alterations and facial telangiectasias. There continues to be a growing interest in the efficacy of intense pulsed light (IPL) devices in the treatment of skin aging, as well as further defining its mechanism of action. OBJECTIVES: The objective of this clinical trial was to evaluate the effects and the mechanism of action of an IPL by comparing clinical photographs and biopsy results before and after treatment. METHODS: A total of 58 patients were treated using a new IPL device. Clinical photographs were taken before treatment and compared to those taken 3 weeks after the treatment. Also, 4 cases had pathological analyses of tissues that were stained by haematoxylin-eosin and Uana orcein. Immunohistology of human collagen of types 1 and 3 and quantitative analyses of elastin and collagen were performed by a poly-functional digital image light microscope; a transmission electron microscope was used for 2 of the cases to look for additional changes. RESULTS: After 3 treatments, 62.1% of the patients showed improvement in wrinkles and skin texture. Pigmentation improved in 84.6% of the patients, and a reduction in telangiectasis was seen in 81.25% of the patients. Pathological examination showed that both type 1 and type 3 collagens increased following treatment, but elastin content decreased; however, the elastin fibers were arranged more neatly. In the transmission electron microscope study, the amount of fibroblast activity increased, the fibroblasts were more active, and there were more collagen fibers neatly rearranged within the stroma. CONCLUSION: Clinical and pathological studies demonstrated that the IPL was effective in improving wrinkles and skin texture. The mechanism of action may be through the increasing activity of the fibroblasts, hyperplasia of the fibroblasts, and rearrangement of both collagen and elastin within the stroma.

Photodermatol Photoimmunol Photomed. 2008 Feb;24(1):49-51.

Effect of a new infrared light device (1100-1800 nm) on facial lifting.

Ahn JY<>, Han TY<>, Lee CK<>, Seo SJ<>, Hong CK<>.

Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, South Korea.

Laser skin resurfacing procedures can be classed into two categories – invasive and non-invasive. The last several decades have witnessed a host of advancements in ablative laser therapy and other ablative modalities for the rejuvenation of skin, including the CO(2) laser, the erbium : yttrium aluminum garnet laser, chemical peels, and dermabrasion. Despite the excellent results that can result from the practice of these techniques by experienced surgeons, the invasive nature of these devices is associated with inherent risks and patient discomfort. Therefore, much of the focus has been on non-ablative lasers and intense-pulsed light devices. We evaluated the efficacy and safety of treatment with the new infrared light device (1100-1800 nm), Titan, and assessed the degree of improvement associated with two-time laser treatments, as compared to one-time laser treatment.

J Cosmet Laser Ther. 2008 Jun;10(2):67-71.

Facial skin tightening with an 1100-1800 nm infrared device.

Carniol PJ<>, Dzopa N<>, Fernandes N<>, Carniol ET<>, Renzi AS<>.

PJClaser@aol.com

BACKGROUND/OBJECTIVES: To determine the efficacy of the 1100-1800 nm infrared device for facial and cervical skin tightening. METHODS: Ten female patients, with a mean age of 56.5 years, received two treatments 1 month apart with a chilled tip infrared device (Titan; Cutera, Brisbane, CA, USA). Individuals were examined and photographed prior to treatment and at 1 and 3 months post-treatment. Three treatment-independent evaluators compared the photographs and graded them on a standardized scale applied to seven regions subdividing the face and neck. After evaluating the photographs, the difference in pretreatment and post-treatment scores was expressed as a percentage. The patients also rated their results. RESULTS/CONCLUSION: The greatest tightening was achieved over the malar region, the upper neck and the body of the mandible. In these areas the average tightening was 10%, 10%, and 12% respectively. The patients reported a 32% improvement in the appearance of their cheeks and a 20% visible improvement in their necks. Overall, they were pleased with the result of this non-surgical skin tightening.

Aesthetic Plast Surg. 2008 May;32(3):523-30.

Effects achieved on stretch marks by a nonfractional broadband infrared light system treatment.

Trelles MA<>, Levy JL<>, Ghersetich I<>.

Instituto Médico Vilafortuny/Antoni de Gimbernat Foundation, Avda. Vilafortuny, 31, E-43850 Cambrils, Spain. imv@laser-spain.com

BACKGROUND: Infrared light systems reportedly produce collagen-related effects, enabling the treatment of several skin disorders. This study was designed to evaluate effects on stretch marks from an intense pulsed light infrared device, which achieved high fluences with high-frequency stacked pulses on selected areas.

METHODS: For this study, 10 patients were recruited for treatment with the NovaPlus infrared device. Three passes per session over four sessions were given 15 days apart. The patients were advised to maintain their weight throughout the study period to avoid any impact on stretch marks. Objective evaluation was performed by using a computer program to compare photographs taken before and 3 months after the last session. Three-dimensional (3D) skin surface analysis also was performed using scores of “worse,” “same,” “fair,” “better,” and “much better.” Biopsies were taken immediately before the first treatment and 3 months after the last session. Also, responses to questionnaires were evaluated to determine the patients’ satisfaction index.

RESULTS: Few patients noted improvement. Photographs of stretch marks checked by computer analysis and 3D skin surface imagery gave a practically equal outcome, with no “worse” or “much better” results. However, these objective tests demonstrated greater improvement than shown by the clinician and patient findings. Histology showed positive changes in the epidermis and dermis related to improvement in tissue condition. The satisfaction index from the questionnaires was average. The authors recognize that the small number of subjects possibly limited the statistical power of the study.

CONCLUSIONS: Objective improvement observed in the overall skin condition did not match the visual observation. The absence of side effects or complications and good compliance with the treatment suggest that extra treatment sessions with the infrared light device could be tried to obtain a better outcome.

J Cutan Med Surg. 2008 May-Jun;12(3):107-13.

Hand rejuvenation using intense pulsed light.

Goldman A<>, Prati C<>, Rossato F<>.

Department of Dermatology, Laser and Plastic Surgery, Clinica Goldman, Porto Alegre, RS, Brazil. alberto@goldman.com.br

BACKGROUND: The aging of the hands is typically characterized by wrinkles, skin thinning, and solar lentigines. The search for effective treatments has led to the use of laser and intense pulsed light (IPL) technologies.

OBJECTIVE: To assess the effectiveness of an IPL device for the improvement of dyspigmentation and overall skin quality on the dorsa of the hands.

METHODS: Twenty-three patients with sun damage and solar lentigines on the dorsal hands were treated with four IPL sessions at 3- to 4-week intervals. Prior to treatment, photographs were taken and informed consent was obtained. Pre- and post-treatment photography and investigator clinical assessment and patient questionnaires were collected for data analysis.

RESULTS: After four treatment sessions, good to excellent results in the improvement in solar lentigines and skin quality were assessed by investigators in 100% of the cases and in 86.94% (20 of 23 subjects) by patient self-assessments. No significant side effects were observed.

CONCLUSION: IPL is an effective and safe treatment option to improve solar lentigines and skin texture for hand rejuvenation.

Aesthetic Plast Surg. 2008 May;32(3):523-30.

Effects achieved on stretch marks by a nonfractional broadband infrared light system treatment.

Trelles MA<>, Levy JL<>, Ghersetich I<>.

Instituto Médico Vilafortuny/Antoni de Gimbernat Foundation, Avda. Vilafortuny, 31, E-43850 Cambrils, Spain. imv@laser-spain.com

BACKGROUND: Infrared light systems reportedly produce collagen-related effects, enabling the treatment of several skin disorders. This study was designed to evaluate effects on stretch marks from an intense pulsed light infrared device, which achieved high fluences with high-frequency stacked pulses on selected areas.

METHODS: For this study, 10 patients were recruited for treatment with the NovaPlus infrared device. Three passes per session over four sessions were given 15 days apart. The patients were advised to maintain their weight throughout the study period to avoid any impact on stretch marks. Objective evaluation was performed by using a computer program to compare photographs taken before and 3 months after the last session. Three-dimensional (3D) skin surface analysis also was performed using scores of “worse,” “same,” “fair,” “better,” and “much better.” Biopsies were taken immediately before the first treatment and 3 months after the last session. Also, responses to questionnaires were evaluated to determine the patients’ satisfaction index.

RESULTS: Few patients noted improvement. Photographs of stretch marks checked by computer analysis and 3D skin surface imagery gave a practically equal outcome, with no “worse” or “much better” results. However, these objective tests demonstrated greater improvement than shown by the clinician and patient findings. Histology showed positive changes in the epidermis and dermis related to improvement in tissue condition. The satisfaction index from the questionnaires was average. The authors recognize that the small number of subjects possibly limited the statistical power of the study.

CONCLUSIONS: Objective improvement observed in the overall skin condition did not match the visual observation. The absence of side effects or complications and good compliance with the treatment suggest that extra treatment sessions with the infrared light device could be tried to obtain a better outcome.

Actas Dermosifiliogr. 2008 May;99(4):262-8.

Recent advances in laser therapy and other technologies

 

[Article in Spanish]

Boixeda P<>, Calvo M<>, Bagazgoitia L<>.

Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, España. phoixeda@gmail.com<>

Laser technology and other energy sources are rapidly finding a place in dermatology clinics. In the field of skin rejuvenation by fractional photothermolysis, although few controlled studies have been undertaken, several devices have emerged in recent years that appear less effective than laser ablation techniques but that are safer. The aim of this short article is to provide an introduction, though not treat in depth, the different emerging technologies in dermatology. We will focus particularly on lasers and light sources in improving applications such as the treatment of vascular lesions, acne, and encapsulated ink tattoos; light-emitting diodes; developments in the treatment of cellulitis; photodynamic therapy; suction methods; scarring; and finally the recent and doubtlessly future introduction of home devices for use in a range of dermatologic applications (depilation, rejuvenation, treatment of acne, etc).

J Cosmet Dermatol. 2008 Mar;7(1):30-4.

Use of light-emitting diode photomodulation to reduce erythema and discomfort after intense pulsed light treatment of photodamage.

Khoury JG<>, Goldman MP<>.

La Jolla SpaMD, La Jolla, CA 92037, USA.

OBJECTIVES: This study evaluates the use of light-emitting diode (LED) photomodulation therapy to accelerate resolution of post-intense pulsed light (IPL) erythema.

METHODS: In this split-face study, 15 subjects were randomized to receive LED treatment to one side of the face as determined by computer-generated randomization numbers. All 15 subjects received a single IPL treatment for facial photodamage. Immediately after IPL treatment, one side of the face was treated for 35 s with the LED device. The other side was not treated. Subjects returned 24 h later for a second LED treatment on the same side of the face. Posttreatment erythema was rated on both sides of the face by the blinded investigator and by subjects immediately after IPL treatment, 24 h later, and 1 week later on a scale of 0% (no erythema) to 100% (severe erythema). Patients commented on posttreatment discomfort immediately after IPL treatment.

RESULTS: Mean erythema scores on the first visit were significantly higher (P = 0.0054) on the side not treated with LED (52.7 +/- 24.6) than on the LED-treated side (43.3 +/- 21.9). Visit 2 data showed a similar trend (P = 0.0281). The subjects reported similar findings with mean erythema scores on the first visit on the LED-treated side (46.7 +/- 25.3) compared with the untreated side (60.0 +/- 23.3); the difference was significant (P = 0.0382). On the second visit, the mean erythema scores trended lower on the LED-treated side (24.3 +/- 22.1) than on the untreated side (27.9 +/- 25.8), but the difference did not reach statistical significance (P = 0.1365). Erythema scores on both facial sides were 0 for all subjects 1 week after IPL treatment. Four patients commented that posttreatment discomfort was considerably less on the LED-treated side immediately after treatment.

CONCLUSION: LED photomodulation treatment may accelerate the resolution of erythema and reduce posttreatment discomfort in IPL-treated patients with photodamage.

Aesthet Surg J. 2008 Mar-Apr;28(2):180-8.

Tissue tightening technologies: fact or fiction.

Sadick N<>.

Dermatology at Weill Cornell Medical College, New York, NY, USA.

Skin laxity is associated with chronological aging and exposure to solar radiation. The authors summarize the advantages and limitations of current laser, light-, and radiofrequency (RF)-based technologies purported to treat skin laxity by effecting heat-induced collagen contraction and subsequent remodeling during the months after treatment. Although penetration of laser or broadband light to the deep dermal layers is limited because of scattering of the light by epidermal melanin, a new device in which broadband infrared light is minimally scattered may overcome these limitations. RF energy offers a treatment alternative that has not only been proven to promote collagen contraction and remodeling but also is not scattered by epidermal constituents. Recently launched devices that use combinations of optical and RF energy achieve clinical benefits at lower and therefore safer levels of energy, with only mild pain and few adverse effects. A combined infrared-RF device takes maximum advantage of both optical and RF technologies to achieve the desired clinical effect. The electrooptical synergy systems have proven to be safe, effective, reliable, and user-friendly. Other more advanced powerful technologies may also be effective in this setting.

Lasers Surg Med. 2008 Feb;40(2):106-12.

LED photoprevention: reduced MED response following multiple LED exposures.

Barolet D<>, Boucher A<>.

RoseLab, Skin Optics Laboratory, Montreal, Quebec, Canada. dbarolet@opusmed.com

BACKGROUND AND OBJECTIVES: As photoprotection with traditional sunscreen presents some limitations, the use of non-traditional treatments to increase skin resistance to ultraviolet (UV) induced damage would prove particularly appealing. The purpose of this pilot study was to test the potential of non-thermal pulsed light-emitting diode (LED) treatments (660 nm) prior to UV exposure in the induction of a state of cellular resistance against UV-induced erythema.

STUDY DESIGN/MATERIALS AND METHODS: Thirteen healthy subjects and two patients with polymorphous light eruption (PLE) were exposed to 5, 6, or 10 LED treatments (660 nm) on an EXPERIMENTAL anterior thigh region. Individual baseline minimal erythema doses (MED) were then determined. UV radiation was thereafter performed on the LED EXPERIMENTAL and CONTROL anterior thigh areas. Finally, 24 hours post-UV irradiation, LED pre-treated MED responses were compared to the non-treated sites.

RESULTS: Reduction of erythema was considered significant when erythema was reduced by >50% on the LED-treated side as opposed to CONTROL side. A significant LED treatment reduction in UV-B induced erythema reaction was observed in at least one occasion in 85% of subjects, including patients suffering from PLE. Moreover, there was evidence of a dose-related pattern in results. Finally, a sun protection factor SPF-15-like effect and a reduction in post-inflammatory hyperpigmentation were observed on the LED pre-treated side.

CONCLUSIONS: Results suggest that LED based therapy prior to UV exposure provided significant protection against UV-B induced erythema. The induction of cellular resistance to UV insults may possibly be explained by the induction of a state a natural resistance to the skin via specific cell signaling pathways and without the drawbacks and limitations of traditional sunscreens. These results represent an encouraging step towards expanding the potential applications of LED therapy and could be useful in the treatment of patients with anomalous reactions to sunlight.

Indian J Dermatol. 2008;53(2):49-53.

Latest laser and light-based advances for ethnic skin rejuvenation.

Elsaie ML<>, Lloyd HW<>.

Dermatology and Cutaneous Surgery Department, University of Miami Cosmetic Center, Fl, USA.

BACKGROUND: Advances in nonablative skin rejuvenation technologies have sparked a renewed interest in the cosmetic treatment of aging skin. More options exist now than ever before to reverse cutaneous changes caused by long-term exposure to sunlight. Although Caucasian skin is more prone to ultraviolet light injury, ethnic skin (typically classified as types IV to VI) also exhibits characteristic photoaging changes. Widespread belief that inevitable or irreversible textural changes or dyspigmentation occurs following laser- or light-based treatments, has been challenged in recent years by new classes of devices capable of protecting the epidermis from injury during treatment.  OBJECTIVE: The purpose of this article is to review recent clinical advances in the treatment of photoaging changes in ethnic skin. This article provides a basis for the classification of current advances in nonablative management of ethnic skin.

Lasers Surg Med. 2008 Feb;40(2):146-52.

A prospective, split face, single-blinded study looking at the use of an infrared device with contact cooling in the treatment of skin laxity in Asians.

Chan HH<>, Yu CS<>, Shek S<>, Yeung CK<>, Kono T<>, Wei WI<>.

Division of Dermatology, Department of Medicine, University of Hong Kong, Hong Kong SAR, China. hhlchan@hku.hk

BACKGROUND: Although monopolar radiofrequency treatment is effective in the improvement of skin laxity, the pain and cost that are associated with this method suggest the need for alternative treatment options. Recently, an infrared device with contact cooling has been shown to be effective in the treatment of skin laxity, with ultrastructural changes observed that are similar to those that are observed following treatment with a monopolar radiofrequency device. However, no control was included in previous studies.

OBJECTIVE: To conduct a prospective, split-face, single-blinded study to look at the efficacy and complications among Asians of treatment for skin tightening with an infrared device with contact cooling.

METHOD: Thirteen Chinese women were treated. An infrared device with contact cooling (Titan, Cutera, Brisbane, CA) was used to treat one side of the face and the untreated side served as the control. The treatment was performed twice with a 4-week interval between the treatments and the patients were followed up by subjective assessment using a structured questionnaire 1 and 3 months after the second (and last) treatment. In all cases, pre- and post-treatment clinical photographs were taken. Two independent observers assessed the photographs.

RESULTS: Twenty-three percentage of patients reported mild improvement, 15% reported moderate improvement, and 54% reported significant improvement 3 months after their second (and last) treatment. In terms of objective assessment, 41% of patients were identified to have some degree of improvement of the treated side 3 months after their second treatment. Compared with the untreated side, the treated side improved significantly (P = 0.031) at 1 and 3 months after the second treatment. Blistering occurred in one patient, which had resolved completely by the 3-month follow-up visit.

CONCLUSION: An infrared device with contact cooling can be used effectively and safely for the treatment of skin laxity, especially in smaller anatomical areas.

Dermatol Ther. 2007 Nov-Dec;20(6):414-29.

Nonablative laser rejuvenation in men.

Ross EV<>.

Dermatology Division, Scripps Clinic-Laser and Cosmetic Dermatology Center, San Diego, California 92130, USA. Vic_ross@msn.com

As our culture increasingly emphasizes youth and virility in the workplace, men have become interested in enhancing their appearance. Once confined to a small number of “progressive” urban patients, the ever-enlarging buffet of minimally invasive procedures has broadened the appeal for laser rejuvenation. Although most procedures are gender neutral, there are sex-specific characteristics that should be considered in designing logical laser strategies for men. In this review, the major categories of rejuvenation are examined in a modality- and application-specific manner. When possible, settings are discussed for particular devices. The reader should be aware, however, that “go-by” recipes, although enticing for the novice, should only be applied within the context of identifiable tissue endpoints and with properly functioning equipment. The best settings are those that achieve desired results for a specific device, and ultimately, experience is the best guide for optimal parameter selection.

J Drugs Dermatol. 2007 Oct;6(10):1024-8.

Intense pulsed light versus advanced fluorescent technology pulsed light for photodamaged skin: a split-face pilot comparison.

Braun M<>.

Vancouver Laser & Skin Care Centre Inc, Vancouver, BC, Canada. info@vancouverlaser.com

Intense pulsed light (IPL) has been a popular nonablative treatment of photodamage. A prospective, randomized, controlled, single-blinded, split-face pilot study compared the efficacy and safety of 2 multitechnology broadband pulsed light platform devices: an IPL device (Lumenis One, Lumenis Corporation, Santa Clara, CA) and a fluorescent pulsed light with advanced fluorescent technology (AFT, Harmony System, Alma Lasers, Buffalo Grove, IL) device. Eight volunteer subjects (skin types I-IV) with a 2.0 mean Global Score for Photoaging (scale 0-4) participated in the study. Subjects received 3 to 5 treatments 3 weeks apart in which one side of the face was treated with the IPL device and the other side with the AFT device. During each treatment session, the face received 3 complete passes without anesthesia. Treatment was aggressive and parameters were determined by test spot application. Treatment endpoints were mild erythema. Results were evaluated by clinical observations of the investigator and comparison of pre- and post-treatment photographs by subjects and 2 blinded dermatologists. Blinded evaluators agreed that improvements in dyspigmentation, telangiectasias, erythema, and skin texture were similar on both sides of the face. Subject assessments of discomfort during treatment were also comparable. Adverse effects were not observed.

Clin Dermatol. 2007 Sep-Oct;25(5):434-42.

 

Masers to magic bullets: an updated history of lasers in dermatology.

 

Houk LD<>, Humphreys T<>.

Department of Dermatology and Cutaneous Biology, Jefferson Medical College of Thomas Jefferson University, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Laser therapy is one of the fastest expanding and most exciting fields in dermatology. From its theoretical beginnings in Einstein’s imagination, lasers have come to be used in treatments for conditions ranging from skin malignancy and acne to hirsutism and photoaging. We will briefly review the evolution of laser treatment, with a focus on the recent developments surrounding the new millennium.

Clin Dermatol. 2007 Sep-Oct;25(5):474-9.

Nonablative tissue remodeling and photorejuvenation.

DeHoratius DM<>, Dover JS<>.

Department of Dermatology, Section of Dermatologic and Cutaneous Oncology, Yale University School of Medicine, New Haven, CT 03536, USA.

Nonablative facial resurfacing is a noninvasive approach to tissue remodeling and skin rejuvenation. These procedures are considered an alternative to the more traditional laser resurfacing with less dramatic effects, but also with significantly less downtime. Results vary based on the lasers and light sources used. In general, the infrared lasers improve texture, visible light lasers somewhat improve texture but greatly reduce redness and telangiectasias, and intense pulsed light devices improve both red targets and brown discoloration, as well as skin texture. Lastly, low-energy devices may improve redness and texture modestly. Patient selection, as well as device selection, is based on the outcome desired. Side effects are uncommon and preventable.

J Cosmet Dermatol. 2007 Sep;6(3):189-94.

The use of light-emitting diode therapy in the treatment of photoaged skin.

Baez F<>, Reilly LR<>.

International Center for Cosmetic Medicine, Sydney, NSW, Australia. fbaez@optusnet.com.au

BACKGROUND: Light-emitting diode (LED) therapy is an increasingly popular methodology for the treatment of sun damage. Combination use of light wavelengths reported to stimulate collagen synthesis and accelerate fibroblast-myofibroblast transformation may display a composite rejuvenative effect. OBJECTIVE: To clinically assess reduction in sun damage signs following a 5-week course of LED therapy and to assess subject’s perception of the treatment. METHODS: Thirteen subjects with wrinkles or fine lines in the periorbital and nasolabial region and those presenting Glogau scale photodamage grade II-III received nine 20-min duration light treatments using the Omnilux LED system. The treatments combined wavelengths of 633 and 830 nm at fluences of 126 and 66 J/cm(2), respectively. Sun-damage reduction was assessed at 6, 9, and 12 weeks by clinical photography and patient satisfaction scores. RESULTS: The majority of subjects displayed “moderate” (50%) or “slight” (25%) response to treatment at investigator assessment. Treatment of the periorbital region was reported more effective than the nasolabial region. At 12-week follow-up, 91% of subjects reported improved skin tone, and 82% reported enhanced smoothness of skin in the treatment area. CONCLUSION: Good response to LED therapy has been shown in this modest sample. Larger trials are needed to assess optimum frequency of light treatments and overall treatment time.

Facial Plast Surg Clin North Am. 2007 May;15(2):179-84, vi.

Cervical facial skin tightening with an infrared device.

Bunin LS<>, Carniol PJ<>.

The Paragon Centre, 1611 Pond Road, Suite #403, Allentown, PA 18104, USA. lbuninmd@yahoo.com

Improvement of facial and cervical skin laxity has been difficult to achieve without surgical procedures. A device called the Titan, (Cutera, Inc., Brisbane, California) uses infrared light to volumetrically heat the dermis. It is designed to thermally induce collagen contraction, with subsequent collagen remodeling and neocollagen synthesis. The epidermis is protected via pre-, parallel, and post-treatment cooling. Because there is minimal to no discomfort during the procedure, no anesthesia is necessary. With this device, improvements in skin laxity and facial and neck contours have been achieved. Results can vary, however. This variation may be caused by patient selection variability and differences in technique. This article presents an effective approach to patient selection, evaluation, and treatment planning, and a detailed treatment protocol.

Zhonghua Yi Xue Za Zhi. 2007 May 29;87(20):1394-7.

Effects of rejuvenation by intense pulsed light and basic mechanism thereof

[Article in Chinese]

Feng YJ<>, Zhao JY<>.

Department of Dermatology, Beijing Friendship Hospital Affiliated to the Capital University of Medical Sciences, Beijing 100050, China.

OBJECTIVE: To evaluate the effects of rejuvenation by intense pulsed light (IPL) and the mechanism thereof.

METHODS: Fifty-eight patients with photo aging were treated with IPL of single, double, or triple pulse pattern for 3 – 5 times with the intervals of 3 – 4 weeks. Three weeks after the last treatment, photography was conducted and the pictures underwent grading by the physicians and patients according to blind method. Skin specimens of the posteroinferior ear lobe or the nape were obtained from 4 patients to undergo HE staining, Uana orcein staining of elastin, immunohistochemical staining for collagenous fibers of types I and III, and transmission electron microscopy was conducted in 2 of the 4 patients. Skin digitalized image analysis was conducted on 34 female patients to measure and analyze the depth and width of dermatographs, roughness of skin.

RESULTS: After the third treatment, the wrinkles and skin texture of 62.1% of the patients showed improvement, and 84.60% of the pigmented lesions and 81.25% of the vascular lesions showed improvement. Pathology showed that type I and type III collagen increased while elastin decreased, and the fibers were orderly re-arranged. Transmission electron microscopy showed that after treatment the fibroblasts increased in number and became more active in secretion and there were more collagen fibers orderly re-arranged in the stroma. Digitalized image analysis showed significant improvement in skin smoothness, depth, arithmetic average roughness and average roughness of skin texture (all P < 0.01).

CONCLUSION: IPL is effective to improve the skin texture. The mechanism may be the increasing of the activity of the fibroblasts, and hyperplasia and re-arrangement of collagen and elastin.

Acta Chir Plast. 2007;49(2):47-50.

Rejuvenation of the aging face using fractional photothermolysis and intense pulsed light: a new technique.

Mezzana P<>, Valeriani M<>.

Gestione Servizi Medici e Chirurgici, Laser Centre, Rome, Italy. pmezzana@yahoo.it

Photoaging is an inevitable occurrence for people who have a fair skin type, who live in a sunny climate, and who enjoy the outdoors. In the past the remedies for this condition were limited to dermabrasion or chemical peeling. Both dermabrasion and chemical peels have hazards of their own. With phenol peels, cardiac and renal toxicity was real concern. There is an increasing demand for an effective and safe laser treatment that repairs photoaged skin. Two treatment modalities, ablative skin resurfacing (ASR), and nonablative dermal remodeling (NDR), have been developed to address this demand. All currently available laser treatments, however, exhibit significant problems, and these laser systems typically operate safely and effectively only over a narrow, patient-dependent treatment range. This study aimed to analyze a new protocol of fractional rejuvenation and intense pulsed light for skin rejuvenation regarding its efficacy, safety, and complications. Twenty-nine patients (27 women and 2 men), age ranging from 40 to 73 years, answered the questionnaire and were included in the study. The use of intense pulsed light after the fractional rejuvenation allows us to enhance the effects of this new procedure especially in skin pigmentation disorders and telangiectasia and to continue to stimulate the deep dermal component.

Dermatol Surg. 2006 May;32(5):601-10.

Near [corrected] painless, nonablative, immediate skin contraction induced by low-fluence irradiation with new infrared device: a report of 25 patients.

Ruiz-Esparza J<>.

University of California, San Diego, California, USA. jarues@earthlink.net

Erratum in:

  • Dermatol Surg. 2006 Jun;32(6):preceding 773.

BACKGROUND: Nonablative radiofrequency (NARF) has been the only method for producing noninvasive skin tightening. Nevertheless, significant pain during the procedure is an important downside of this technology. A new nonablative medical device, Titan (Cutera, Inc., Brisbane, CA, USA), capable of fluences much lower than those possible with NARF, was tested as a less painful alternative. OBJECTIVES: To produce skin contraction leading to lifting of eyebrows and/or improvement of lower face and neck skin laxity using fluences below pain levels. PATIENTS AND METHODS: Twenty-five patients were treated. Standardized photographs were obtained preoperatively, after a few days, a few weeks, and up to 12 months after the procedure. RESULTS: Immediate changes were obtained in 22 of 25 patients. Examination of photographs revealed that the initial improvement was maintained throughout the follow-up period. CONCLUSION: Immediate true skin contraction persisting through the immediate, intermediate, and long-term follow-up was found in the vast majority of patients in this group. Edema as an artifact simulating immediate improvement was excluded by serial photographs taken during the follow-up period. Skin contraction occurred at low fluences, below the threshold of pain. This, to the best of our knowledge, has not been previously described in the medical literature.

Lasers Med Sci. 2007 Mar;22(1):1-3. Epub 2006 Nov 25.

A reasonable mechanism for visible light-induced skin rejuvenation.

Lubart R<>, Friedmann H<>, Lavie R<>, Longo L<>, Jacobi J<>, Baruchin O<>, Baruchin AM<>.

Department of Chemistry, Bar-Ilan University, Ramat-Gan, 52900, Israel.

In recent years, much research has been done in the field of non-ablative skin rejuvenation. This comes as a response to the continuous demand for a simple method of treating rhytides, UV exposure, and acne scars. Numerous researches involve visible light-pulsed systems (20-30 J/cm(2)). The mechanism of action is believed to be a selective heat-induced denaturalization of dermal collagen that leads to subsequent reactive synthesis (Bitter Jr., Dermatol. Surg., 26:836-843, 2000; Fitzpatrick et al., Arch. Dermatol., 132:395-402, 1996; Kauvar and Geronemus, Dermatol. Clin., 15:459-467, 1997; Negishi et al., Lasers Surg. Med., 30:298-305, 2002; Goldberg and Cutler, Lasers Surg. Med., 26:196-200, 2000; Hernandez-Perez and Ibeitt, Dermatol. Surg., 28:651-655, 2002). In this study, we suggest a different mechanism for photorejuvenation based on light-induced reactive oxygen species (ROS) formation. We irradiated collagen in vitro with a broadband of visible light (400-800 nm, 24-72 J/cm(2)) and used the spin trapping coupled with electron paramagnetic resonance spectroscopy to detect ROS. Irradiated collagen resulted in hydroxyl radicals formation. We propose, as a new concept, that visible light at the energy doses used for skin rejuvenation (20-30 J/cm(2)) produces high amounts of ROS, which destroy old collagen fibers, encouraging the formation of new ones. On the other hand, at inner depths of the skin, where the light intensity is much weaker, low amounts of ROS are formed, which are well known to stimulate fibroblast proliferation.

Dermatol Surg. 2007 Feb;33(2):146-51.

Nonablative infrared skin tightening in Type IV to V Asian skin: a prospective clinical study.

Chua SH<>, Ang P<>, Khoo LS<>, Goh CL<>.

National Skin Center, 1 Mandalay Road, Singapore 308205. shchua@nsc.gov.sg

BACKGROUND: Nonablative skin tightening devices have been developed to treat facial and neck skin laxity without damage to the epidermis. There are at present two main approaches: the pioneer method by monopolar radiofrequency and the second by infrared light. OBJECTIVE: This study aims to determine the clinical efficacy and safety of nonablative infrared light in the treatment of facial and neck skin laxity in Type IV to V Asian skin. METHODS: This is a prospective noncomparative open study. Adult patients with facial and neck skin laxity were recruited for the study. Three treatment sessions spaced 4 weeks apart were performed. Photographic documentation was performed serially during the study period. Final clinical assessment was performed 6 months after the last treatment. Response parameters included patient self-assessment as well as doctor’s assessment. RESULTS: Twenty-one patients were evaluated. All patients were of Fitzpatrick skin types IV and V. Patient assessments of response at 6 months after treatment were as follows: 19% reported mild improvement, 38% reported moderate improvement, and 43% reported good improvement. Doctor’s assessments of photographs before and 6 months after treatment showed observable lifting of sagging skin folds in 86% of patients. Of these, 28% were assessed as significant-mild, 38% as significant-moderate, and 19% as significant-excellent. The treatments were associated with minimal pain and edema. The main side effect was isolated superficial blistering in 7 episodes of 63 treatments performed, which resolved without scarring in all patients. CONCLUSION: Direct application of infrared light with epidermal cooling is effective in achieving mild to moderate gradual clinical improvement in the treatment of facial and neck skin laxity. The procedure is associated with minimal downtime and is safe for use in darker skin, Types IV and V.

Combination 532-nm and 1064-nm lasers for noninvasive skin rejuvenation and toning.

Lee MW<>.

The East Bay Laser & Skin Care Center, Walnut Creek, CA 94598, USA. eastbaylaser@aol.com

BACKGROUND: Noninvasive techniques for skin rejuvenation are quickly becoming standard in the treatment of mild rhytids and overall skin toning. Multiple laser wavelengths and modalities have been used with varying degrees of success, including 532-nm, 585-nm, 1064-nm, 1320-nm, 1450-nm, and 1540-nm wavelengths.

OBJECTIVES: To evaluate a combination technique using a long-pulsed, 532-nm potassium titanyl phosphate (KTP) laser and a long-pulsed 1064-nm Nd:YAG laser, separately and combined, for noninvasive photorejuvenation and skin toning and collagen enhancement and to establish efficacy and degree of success.

DESIGN: Prospective nonrandomized study with longitudinal follow-up.

SETTING: Private dermatologic surgery and laser practice.

METHODS: A total of 150 patients, with skin types I through V, were treated with long-pulsed KTP 532-nm and long-pulsed Nd:YAG 1064-nm lasers, separately and combined. For the KTP 532-nm laser, the fluences varied between 7 to 15 J/cm2 at 7- to 20-millisecond pulse durations with a 2-mm handpiece and 6 to 15 J/cm2 at 30- to 50-millisecond pulses with a 4-mm handpiece. The 1064-nm Nd:YAG laser fluences were set at 24 to 30 J/cm2 for a 10-mm handpiece. These energies were delivered at 30- to 65-millisecond pulse durations. All subjects were treated at least 3 times and at most 6 times, depending on patient satisfaction level, at monthly intervals and were observed for up to 18 months after the last treatment.

MAIN OUTCOME MEASURES: All patients were asked to fill out a “severity scale” on which redness, pigmentation, rhytids, skin tone/tightness, texture, and patient satisfaction were noted before and after each treatment. Redness, pigmentation, rhytids, skin tone/tightness, and texture were also evaluated by the physician and another observer.

RESULTS: After 3 to 6 treatments, 50 patients treated with the 532-nm KTP laser alone showed improvement of 70% to 80% in redness and pigmentation, 30% to 50% in skin tone/tightening, 30% to 40% in skin texture, and 20% to 30% in rhytids. Another 50 patients treated with the 1064-nm Nd:YAG laser alone showed improvement of 10% to 20% in redness, 0% to 10% in pigmentation, 10% to 30% in skin tone/tightening, 20% to 30% in skin texture, and 10% to 30% in rhytids. The third group of 50 patients treated with both KTP and Nd:YAG lasers showed improvement of 70% to 80% in redness and pigmentation, 40% to 60% in skin tone/tightening, 40% to 60% in skin texture, and 30% to 40% in rhytids. Skin biopsy specimens taken at 1-, 2-, 3-, and 6-month intervals demonstrated new collagen formation.

CONCLUSIONS: All 150 patients exhibited mild to moderate improvement in the appearance of rhytids, moderate improvement in skin toning and texture, and great improvement in the reduction of redness and pigmentation. The KTP laser used alone produced results superior to those of the Nd:YAG laser. Results from combination treatment with both KTP and Nd:YAG lasers were slightly superior to those achieved with either laser alone.

J Drugs Dermatol. 2007 Nov;6(11):1114-8.

Treatment of photoaging with a very superficial Er:YAG laser in combination with a broadband light source.

Berlin AL<>, Hussain M<>, Phelps R<>, Goldberg DJ<>.

Skin Laser and Surgery Specialists of NY and NJ, New York, NY 10022, USA.

BACKGROUND AND OBJECTIVE: Studies documenting improvement following combined laser and light-based devices are needed. The objective of this study was to evaluate clinical, histological, and ultrastructural changes in photodamaged facial skin following sequential treatment with ablative superficial erbium:YAG (Er:YAG) laser peels and nonablative intense pulsed light, or broadband light (BBL), treatments. STUDY DESIGN/MATERIALS AND METHODS: Fifteen subjects with photodamaged facial skin and Fitzpatrick skin types I to III underwent 3 monthly treatments with the Profile system (Sciton, Inc, Palo Alto, CA) utilizing very superficial MicroLaserPeel settings of 2.5 to 5.0 J/cm2 and BBL settings of 515-, 560-, or 590-nm filters, 10-msec pulse duration, and fluences of 12 J/cm2. Five subjects underwent pre- and post-treatment postauricular skin biopsies for evaluation of treatment-induced light and electron microscopic changes. RESULTS: Twelve subjects completed the study. Both blinded evaluator and subject assessment of clinical changes documented significant improvement in photodamaged skin, with the greatest improvement achieved in overall appearance and epidermal dyspigmentation. These results were largely maintained at 3 months following the last treatment. Light microscopy showed changes in the epidermis, collagen, and elastic fibers consistent with a wound repair mechanism to the depth of 250 to 350 microns. Electron microscopy revealed a slight decrease in the average collagen fiber thickness, pointing to an increase in type III collagen. CONCLUSION: A protocol utilizing multiple combined superficial Er:YAG ablative treatments and nonablative BBL treatments lead to a significant improvement in the clinical signs of photodamaged skin, with histological and ultrastructural evidence of new collagen formation.

Ann Plast Surg. 2007 Nov;59(5):479-83.

Comparison study of intense pulsed light versus a long-pulse pulsed dye laser in the treatment of facial skin rejuvenation.

Kono T<>, Groff WF<>, Sakurai H<>, Takeuchi M<>, Yamaki T<>, Soejima K<>, Nozaki M<>.

Department of Plastic and Reconstructive Surgery, Tokyo Women’s Medical University, Tokyo, Japan. tkono@prs.twmu.ac.jp

Currently, various nonablative skin resurfacing techniques are being used to rejuvenate facial skin, including lasers and intense pulsed light (IPL). There are few direct comparison studies between IPLs and lasers. The objective of our study is to compare the effectiveness of intense pulsed light versus a long-pulse pulsed dye laser (LPDL) in the treatment of facial skin rejuvenation. Ten Asian patients with Fitzpatrick skin types III-IV were enrolled in this study. One half of the face was treated with IPL (6 treatment sessions) and the other side was treated by LPDL (3 treatment sessions). An LPDL with a wavelength of 595 nm and spot size of 7 mm was used. Utilizing the compression method, lentigines were treated using a PDL with a fluence between 9-12 J/cm and a pulse duration of 1.5 ms. Wrinkles were treated with fluences between 10 to 12 J/cm and a pulse duration of 20 ms, using a pulse-stacking technique. An IPL with a type B handpiece was used. Lentigines and wrinkles were treated with fluences between 27 to 40 J/cm and a pulse duration of 20 ms. The improvement of lentigines was 62.3% and 81.1% for IPL and LPDL respectively. There was no significant difference between IPL and LPDL in wrinkle reduction. There was no scarring or pigmentary change seen with either device. Both IPL and LPDL are effective for facial skin rejuvenation in Asians, but LPDL treatment is significantly better than IPL treatment in the treatment of lentigines. The use of the compression technique may allow this LPDL to be used effectively for facial rejuvenation and with fewer treatment sessions, when compared with the IPL.

J Cosmet Laser Ther. 2007 Sep;9(3):148-60.

Measuring key parameters of intense pulsed light (IPL) devices.

Town G<>, Ash C<>, Eadie E<>, Moseley H<>.

Independent Laser Protection Adviser, Haywards Heath, West Sussex, UK. godfreytown@csi.com

BACKGROUND: Unlike medical lasers, intense pulsed light (IPL) devices are largely unregulated and unclassified as to degree of safety hazard. With the exception of most of the USA, the United Kingdom and parts of Europe, the Far East and Australia, the sale of IPLs is generally unrestricted, with the majority being sold into the beauty therapy and spa markets. Standards are only imposed on manufacturers for technical performance data and operating tolerances determined by CE-compliance under electrical safety standards or the EU Medical Device Directive. Currently, there is no requirement for measurement of key IPL performance characteristics. OBJECTIVE: To identify the key IPL parameters, emphasize their importance in terms of safe and effective treatment and provide examples of preliminary measurement methods. These measurements can highlight changes in an IPL device’s performance, improving patient safety and treatment efficacy. METHODS: Five key parameters were identified as having an important role to play in the way light interacts with the skin, and therefore an important role in patient safety and effective treatment. Simple methods were devised to measure the parameters, which include fluence, pulse duration, pulse profile, spectral output and time-resolved spectral output. RESULTS: The measurement methods permitted consistent and comparable measurements to be made by two of the authors at working clinic locations on 18 popular IPL devices and allowed assessment of output variations. Results showed discrepancies between the measured IPL device outputs and those values displayed on the system or claimed by the manufacturers. The importance of these discrepancies and their impact is discussed. CONCLUSIONS: This study, of 18 popular devices in regular daily use in England and Wales, provides example methods for measuring key IPL device parameters and highlights the need for regular measurement of at least those five key parameters measured in this study. These methods can help service technicians to check performance and eliminate device malfunction.

J Photochem Photobiol B. 2007 Jul 27;88(1):51-67. Epub 2007 May 1.

A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings.

Lee SY<>, Park KH<>, Choi JW<>, Kwon JK<>, Lee DR<>, Shin MS<>, Lee JS<>, You CE<>, Park MY<>.

Department of Dermatology, National Medical Center, 18-79, Euljiro 6-ga, Jung-ku, Seoul, Republic of Korea. drlsy96@hotmail.com

Light-emitting diodes (LEDs) are considered to be effective in skin rejuvenation. We investigated the clinical efficacy of LED phototherapy for skin rejuvenation through the comparison with three different treatment parameters and a control, and also examined the LED-induced histological, ultrastructural, and biochemical changes. Seventy-six patients with facial wrinkles were treated with quasimonochromatic LED devices on the right half of their faces. All subjects were randomly divided into four groups treated with either 830nm alone, 633nm alone, a combination of 830 and 633nm, or a sham treatment light, twice a week for four weeks. Serial photography, profilometry, and objective measurements of the skin elasticity and melanin were performed during the treatment period with a three-month follow-up period. The subject’s and investigator’s assessments were double-blinded. Skin specimens were evaluated for the histologic and ultrastructural changes, alteration in the status of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), and the changes in the mRNA levels of IL-1ss, TNF-alpha, ICAM-1, IL-6 and connexin 43 (Cx43), by utilizing specific stains, TEM, immunohistochemistry, and real-time RT-PCR, respectively. In the results, objectively measured data showed significant reductions of wrinkles (maximum: 36%) and increases of skin elasticity (maximum: 19%) compared to baseline on the treated face in the three treatment groups. Histologically, a marked increase in the amount of collagen and elastic fibers in all treatment groups was observed. Ultrastructural examination demonstrated highly activated fibroblasts, surrounded by abundant elastic and collagen fibers. Immunohistochemistry showed an increase of TIMP-1 and 2. RT-PCR results showed the mRNA levels of IL-1ss, TNF-alpha, ICAM-1, and Cx43 increased after LED phototherapy whereas that of IL-6 decreased. This therapy was well-tolerated by all patients with no adverse effects. We concluded that 830 and 633nm LED phototherapy is an effective approach for skin rejuvenation.

Lasers Med Sci. 2007 Jun;22(2):93-9. Epub 2006 Nov 23.

Facial rejuvenation and light: our personal experience.

Trelles MA<>, Mordon S<>, Calderhead RG<>.

Instituto Médico Vilafortuny, Antoni de Gimbernat Foundation, Cambrils, Spain. imv@laser-spain.com

The treatment of ageing skin remains a very hot topic, and many systems have been reported as having varying degrees of success. Nonablative lasers were developed to avoid the problematic and uncomfortable sequelae following laser ablative resurfacing, and while there was no downtime, there was also poor patient satisfaction. The same was true of the intense pulsed light systems. The use of different modalities in various combinations was found to offer much better results, however, such as a 595-nm pulsed dye laser followed by a 1,450-nm diode laser, and so on, all used at subablative thresholds. The recent entry of blue and infrared tunable plasma light and light-emitting diodes into the skin rejuvenation arena has attracted a great deal of attention. The authors suggest that no single modality can accomplish all the complex events required for effective skin rejuvenation, suggest that combination phototherapy is the best approach combined with an adjunctive epidermal care regimen, and demonstrate their development of this methodology.

J Drugs Dermatol. 2006 Sep;5(8):771-8.

Multicenter clinical perspectives on a broadband infrared light device for skin tightening.

Taub AF<>, Battle EF Jr<>, Nikolaidis G<>.

Advanced Dermatology, Lincolnshire, IL 60069, USA. drtaub@skinfo.com

Modalities for skin tightening include radiofrequency (RF) energy, lasers, and combination RF and diode lasers. A new broadband infrared light device (BILD) (Titan, Cutera, Inc, Brisbane, CA) targets water to achieve dermal heating and collagen remodeling for skin tightening. Although thousands of procedures have been performed worldwide with this device, only one article (to the author’s knowledge) describing its performance in skin tightening has been published. Three US dermatologists report their experience with and provide their perspective on facial skin tightening with the BILD system. As early adopters, they each have 12 to 18 months experience with this system. One author (A.F.T.) treated 42 patients twice at 1-month intervals over 18 months. The mean improvement score was 1.83 (scale 0 to 4, with 4 denoting maximum improvement) with an average follow-up time of 3.7 months. More than 90% of treated patients showed visible improvement. No complications were observed and patient satisfaction was high. This paper presents the general consensus of the authors on patient selection and treatment protocol, their modifications of the manufacturer’s treatment protocol, and the outcomes of 42 patients treated by one author (A.F.T.). The observations were gathered separately and turned out to be very similar. The recommendations are presented to help practitioners achieve consistently good results and avoid complications with the BILD procedure.

J Drugs Dermatol. 2006 Sep;5(8):748-53.

Combined 633-nm and 830-nm led treatment of photoaging skin.

Goldberg DJ<>, Amin S<>, Russell BA<>, Phelps R<>, Kellett N<>, Reilly LA<>.

Skin Laser and Surgery Specialists of NY/NJ, New York, NY 10022, USA. drdavidgoldberg@skinandlasers.com

OBJECTIVES: To evaluate the clinical efficacy and ultrastructural changes in photodamaged skin after combined 633-nm and 830-nm light-emitting diode (LED) treatments. METHODS: Thirty-six subjects received 9 LED treatments over the course of 5 weeks and were subsequently evaluated for final clinical improvement 12 weeks after treatment. Five subjects were also biopsied to determine the ultrastuctural posttreatment changes in collagen fibers. RESULTS: A statistically significant improvement in wrinkles was seen after profilometric analysis. The majority of subjects reported improvements in softness, smoothness, and firmness at all time points. Electron microscopic analysis showed evidence of post-LED treatment of thicker collagen fibers. CONCLUSIONS: 633-nm and 830-nm LED treatments play a role in the treatment of photodamaged skin. LED treatments can be used as either a primary or adjunctive treatment modality.

Yonsei Med J.<> 2006 Aug 31;47(4):485-90.

Effects of infrared radiation on skin photo-aging and pigmentation.

Lee JH<>, Roh MR<>, Lee KH<>.

Department of Dermatology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea.

Infrared radiation is increasingly and uncritically used for cosmetic and wellness purposes, despite the poorly understood biologic effects of such treatments on humans. In the present study, we investigated the effects of infrared radiation on collagen and elastin production in dermal fibroblasts, as well as the clinical and histopathologic effects of infrared radiation on photo-aged facial skin lesions. In order to determine the effects of infrared radiation on collagen and elastin production, dermal fibroblasts were exposed to infrared radiation for varying lengths of time and collagen and elastin contents were subsequently determined. Additionally, 20 patients with mild to moderate facial wrinkles and hyperpigmented lesions received daily treatments of far infrared radiation (900 to 1000 microm) for six-months. During the treatment, patients and a medical observer conducted independent photographic and clinical evaluations every 4 weeks, and skin biopsies were obtained for histological analysis at baseline and one month post-treatment. We found that the content of collagen and elastin produced by the fibroblasts increased after infrared radiation, and that this increase was proportional to the duration of irradiation exposure. Following 6 months of treatment, all patients reported good (51-75%) improvements in skin texture and roughness. Additionally, patients noted fair (25-50%) improvement in color tone of the skin; however, improvements in hyperpigmented lesions were not observed. Objective medical evaluation of the patients indicated that roughness and laxity were fairly improved, but there was no significant improvement in hyperpigmented lesions. Histological examination failed to reveal any differences as well. These results suggest that infrared radiation may have beneficial effects on skin texture and wrinkles by increasing collagen and elastin contents from the stimulated fibroblasts. Therefore, skin treatment with infrared radiation may be an effective and safe non-ablative remodeling method, and may also be useful in the treatment of photo-aged skin.

J Cosmet Dermatol. 2006 Mar;5(1):87-91.

Phototherapy in anti-aging and its photobiologic basics: a new approach to skin rejuvenation.

Trelles MA<>.

Instituto Médico Vilafortuny, Antoni de Gimbernat Foundation, Cambrils, Spain. imv@laser-spain.com

Intrinsic aging and photoaging of the face are constantly ongoing, and eventually result in the typical “aged” face, with visible lines and wrinkles at rest, a variety of dyschromia and a tired, dull and lax epidermis over poorly organized elastotic dermal architecture characterized by many interfibrillary spaces. Both ablative and nonablative resurfacing have been reported as solutions, the former providing excellent results, but a long patient downtime, and the latter giving little or no downtime, but less-than-ideal results. In ablative resurfacing, the epidermis is removed and replaced with a “new” epidermis, whereas in the nonablative approach the epidermis is spared through some form of cooling. In both approaches, however, the goal is to create controlled amounts of thermal damage in the dermis to stimulate the wound healing process, thus generating a tighter, better organized, “younger” dermal matrix. A better approach might be to apply prevention, rather than the cure, and to treat subjects in their very early 20s, before even fine lines have begun to appear. This “photoanti-aging” approach could be achieved with the use of very low incident levels of photon energy to stimulate the skin cells, both epidermal and dermal, at cell-specific wavelengths based on the photobiological findings of the literature over the past two decades or so, in order to increase their resistance to the effects of chronological and photoaging. Lasers and IPL systems could be used, but are extremely expensive and therapist-intensive. A new generation of light-emitting diodes (LEDs) has appeared as the result of a spin-off from the US NASA Space Medicine Program, which are much more powerful than the previous generation with quasimonochromatic outputs. These LEDs can offer target specificity to achieve photobiomodulated enhanced action potentials of the skin cells, in particular mast cells, macrophages, endotheliocytes, and fibroblasts, plus increases in local blood and lymphatic flow, in a noninvasive, athermal manner. New phototherapeutic LED-based systems have appeared to meet the need for a less-expensive but clinically useful light source to enable photoantiaging as a reality in clinical practice. Some studies proving the efficacy of LED therapy have already appeared, and based on their results LED therapy represents a potential new approach to prevention in anti-aging, so that further studies are warranted to prove its efficacy.

J Nippon Med Sch. 2006 Apr;73(2):75-81.

Light-emitting diode phototherapy at 630 +/- 3 nm increases local levels of skin-homing T-cells in human subjects.

Takezaki S<>, Omi T<>, Sato S<>, Kawana S<>.

Department of Dermatology, Nippon Medical School, Sendagi, Tokyo, Japan.

BACKGROUND AND AIMS: Red light phototherapy with laser sources has been used successfully for a number of indications. A new generation of quasimonochromatic 630 +/- 3 nm light-emitting diode (LED) systems has recently been yielding good results for the same indications, but no study has examined changes in visible red light irradiated skin at an immunological level. This study was thus designed to examine changes in skin-homing T-cell levels induced in normal human skin by visible red LED energy. SUBJECTS AND METHODS: Six adult male volunteers (35 approximately 48 years old) who satisfied all study criteria had the skin over the lateral aspect of the leg irradiated once per week for 8 weeks with a visible red (630 +/- 3 nm) LED-based system, with irradiance of 105 m/cm2, 15 minutes/session, and a radiant flux of 94 J/cm2. Skin biopsies were performed after the eighth treatment session, and cultures were prepared to assay the type and quantity of skin-homing T-cells using qualitative and quantitative polymerase chain reaction (PCR) techniques. Ultrastructural changes were also assessed with transmission electron microscopy. RESULTS: Transmission electron microscopy revealed mild fibroplastic changes in fibroblasts, with no acute inflammatory changes throughout the treatment session. Qualitative PCR showed the presence of both Th-1 and Th-2 T-cells, and quantitative PCR showed an increase in the numbers of both types of skin-homing T-cells, much more so for Th-2 than for Th-1. CONCLUSIONS: Visible red LED irradiation appears to activate the skin-homing immune system.

J Cosmet Dermatol. 2006 Mar;5(1):87-91.

Phototherapy in anti-aging and its photobiologic basics: a new approach to skin rejuvenation.

Trelles MA<>.

Instituto Médico Vilafortuny, Antoni de Gimbernat Foundation, Cambrils, Spain. imv@laser-spain.com

Intrinsic aging and photoaging of the face are constantly ongoing, and eventually result in the typical “aged” face, with visible lines and wrinkles at rest, a variety of dyschromia and a tired, dull and lax epidermis over poorly organized elastotic dermal architecture characterized by many interfibrillary spaces. Both ablative and nonablative resurfacing have been reported as solutions, the former providing excellent results, but a long patient downtime, and the latter giving little or no downtime, but less-than-ideal results. In ablative resurfacing, the epidermis is removed and replaced with a “new” epidermis, whereas in the nonablative approach the epidermis is spared through some form of cooling. In both approaches, however, the goal is to create controlled amounts of thermal damage in the dermis to stimulate the wound healing process, thus generating a tighter, better organized, “younger” dermal matrix. A better approach might be to apply prevention, rather than the cure, and to treat subjects in their very early 20s, before even fine lines have begun to appear. This “photoanti-aging” approach could be achieved with the use of very low incident levels of photon energy to stimulate the skin cells, both epidermal and dermal, at cell-specific wavelengths based on the photobiological findings of the literature over the past two decades or so, in order to increase their resistance to the effects of chronological and photoaging. Lasers and IPL systems could be used, but are extremely expensive and therapist-intensive. A new generation of light-emitting diodes (LEDs) has appeared as the result of a spin-off from the US NASA Space Medicine Program, which are much more powerful than the previous generation with quasimonochromatic outputs. These LEDs can offer target specificity to achieve photobiomodulated enhanced action potentials of the skin cells, in particular mast cells, macrophages, endotheliocytes, and fibroblasts, plus increases in local blood and lymphatic flow, in a noninvasive, athermal manner. New phototherapeutic LED-based systems have appeared to meet the need for a less-expensive but clinically useful light source to enable photoantiaging as a reality in clinical practice. Some studies proving the efficacy of LED therapy have already appeared, and based on their results LED therapy represents a potential new approach to prevention in anti-aging, so that further studies are warranted to prove its efficacy.

Br J Dermatol. 2005 Dec;153 Suppl 2:57-62.

Cutaneous immunological activation elicited by a low-fluence pulsed dye laser.

Omi T<>, Kawana S<>, Sato S<>, Takezaki S<>, Honda M<>, Igarashi T<>, Hankins RW<>, Bjerring P<>, Thestrup-Pedersen K<>.

Department of Dermatology, Queen’s Square Medical Centre, Yokohama, Japan. tomi@olive.ocn.ne.jp

BACKGROUND: Three years ago, the nonablative wrinkle reduction laser (a 585-nm laser, Chromogenex V3; Chromogenex Light Technologies, Llanelli, U.K.) was developed, and there have already been several reports about its clinical effectiveness. The Chromogenex V3 laser has also been reported to be effective in treating acne and atopic dermatitis. These results suggest that the Chromogenex V3 laser has some immunological role. In this study, we investigated immunological changes elicited by laser irradiation at the ultrastructural level and by analysis of interleukin (IL)-2 and IL-4 mRNA in skin homing T lymphocytes. MATERIALS AND METHODS: Eight healthy adult volunteers (mean age 56.3 years, range 25-66 years) were recruited for this study. Ultrastructural analysis was done 3 h after the laser irradiation, as well as 1 day, 3 days, 1 week, 2 weeks, 4 weeks and 5 weeks later. IL-2 and IL-4 mRNAs in skin homing T cells cultured for 6 weeks were semiquantitatively measured using reverse transcriptase-polymerase chain reaction. RESULTS: Ultrastructural observations revealed that at 3 h after laser therapy, neutrophils, monocytes and mast cells could already be seen in the extravascular dermis. These dermal acute inflammatory changes were observed also at 1 week after laser treatment. Two weeks after laser treatment, the capillaries showed an almost normal structure. Four weeks after laser treatment, many lymphocytes and fibroblasts were observed. The numbers of these lymphocytes increased further at 5 weeks after the laser treatment. One week after the laser irradiation, all subjects were positive for IL-2 mRNA and for IL-4 mRNA. The level of IL-4 mRNA was larger compared with that of IL-2 mRNA in all subjects. CONCLUSION: The Chromogenex V3 is a 585-nm visible light laser, and it may affect the skin not only by selective photothermolysis but also by direct cutaneous immunological activation.

J Cosmet Laser Ther. 2006 Dec;8(4):177-83.

Cutaneous effects compared between higher fluence with fewer treatments and lower fluence with more treatments in a combined IR laser/radio frequency system.

Trelles MA<>, Mordon S<>.

Instituto Médico Vilafortuny/Antoni de Gimbernat Foundation, Cambrils, Spain. imv@laser-spain.com

BACKGROUND AND AIMS: A combined infrared (IR) laser/radio frequency (RF) system has recently been reported to create rejuvenation-related cutaneous effects, but was associated with high levels of pain and some complications. The present study was designed to evaluate the cutaneous effects of the same system with a lower fluence and more treatments. METHODS: Twenty patients were randomly assigned into two groups of 10 individuals each: Group A was treated at 50 J/cm2/100 J/cm3 (laser/RF), respectively, two passes, three treatment sessions 30 days apart; Group B at 30 J/cm2/50 J/cm3, three passes, five treatment sessions 15 days apart. Objective comparisons were made at the same time points with a computer program based on the clinical photography. RESULTS: Group A noted more improvement in wrinkles than Group B at the first assessment, but both groups showed slight and progressive deterioration at the 2- and 6-month assessments. Improved skin appearance was maintained throughout in both groups. The authors recognize that the comparatively small number of subjects possibly limits the statistical power of the study. CONCLUSIONS: Lower fluences and more treatment sessions with the combined 900 nm laser/RF system were complication-free, produced improvements in the overall skin condition and less pain during sessions, suggesting that this combination may produce better patient compliance. Further treatment sessions may improve the results with implications in skin rejuvenation.

J Cosmet Laser Ther. 2005 Dec;7(3-4):177-89.

Optimising the design of a broad-band light source for the treatment of skin.

Clement M<>, Daniel G<>, Trelles M<>.

Swansea University, Singleton Park, Swansea, Wales, SA3 6ED, UK. r.m.clement@swan.ac.uk

Phototherapy has become a treatment of choice in many areas of medicine. Light can be used to deliver energy to tissue selectively targeting specific structures in order to induce the desired therapeutic outcome. The choice of optical parameters for a specific application is not simple. Wavelength, energy, exposure time and fluence can be varied and induce a wide range of tissue effects. The treatment of the skin with light is probably the one phototherapy application that is most developed in terms of technology and market maturity. White light systems are extensively used to address a range of skin conditions. However, different conditions have different physiology and hence require differing optical parameters. The technology standard is based upon systems, which have a number of different optical filters allowing the output to be tailored to the specific application. This paper discusses the advantages of a different type of system, namely the iPulse i300 (Cyden Ltd, Swansea, UK), which uses a single dichroic reflectance filter and whose optical output is changed by varying other parameters in a carefully controlled manner.

Dermatol Ther. 2005 May-Jun;18(3):191-208.

Visible light treatment of photoaging.

Dierickx CC<>, Anderson RR<>.

Skin and Laser Surgery Center, Beukenlaan 52, 2850 Boom, Belgium. cdierickx@cdierickx.be

Recently, a number of new devices have been developed specifically to improve the visible signs of aging in a noninvasive way. These include visible or near-infrared lasers, intense pulsed light sources (IPL), light-emitting diode (LED), and radiofrequency devices. This paper reviews the use of visible light sources and examines the attributes of specific systems for noninvasive skin rejuvenation.

Lasers Med Sci. 2005;20(1):6-10. Epub 2005 May 21.

A single-blinded randomised controlled study to determine the efficacy of Omnilux Revive facial treatment in skin rejuvenation.

Bhat J<>, Birch J<>, Whitehurst C<>, Lanigan SW<>.

Lasercare Clinics, Birmingham Skin Centre, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK.

To determine the efficacy of Omnilux Revive facial treatment in skin rejuvenation, twenty-three volunteers received randomised 20 min treatments three times a week for three weeks to one half of their face, with the untreated side acting as control. Regular assessments were carried out, focusing on parameters of subject satisfaction, photographic assessments, skin elasticity (Cutometer) and skin hydration (Corneometer CM825). Ninety-one percent of the volunteers reported visible changes to their skin. Blinded photographic evaluation reported a clinical response in 59% of the subjects. Objective analysis failed to show statistically significant changes in skin hydration or elasticity. The Omnilux Revive LED lamp is a safe alternative non-ablative skin rejuvenation treatment.

J Cosmet Dermatol. 2006 Mar;5(1):87-91.

Phototherapy in anti-aging and its photobiologic basics: a new approach to skin rejuvenation.

Trelles MA<>.

Instituto Médico Vilafortuny, Antoni de Gimbernat Foundation, Cambrils, Spain. imv@laser-spain.com

Intrinsic aging and photoaging of the face are constantly ongoing, and eventually result in the typical “aged” face, with visible lines and wrinkles at rest, a variety of dyschromia and a tired, dull and lax epidermis over poorly organized elastotic dermal architecture characterized by many interfibrillary spaces. Both ablative and nonablative resurfacing have been reported as solutions, the former providing excellent results, but a long patient downtime, and the latter giving little or no downtime, but less-than-ideal results. In ablative resurfacing, the epidermis is removed and replaced with a “new” epidermis, whereas in the nonablative approach the epidermis is spared through some form of cooling. In both approaches, however, the goal is to create controlled amounts of thermal damage in the dermis to stimulate the wound healing process, thus generating a tighter, better organized, “younger” dermal matrix. A better approach might be to apply prevention, rather than the cure, and to treat subjects in their very early 20s, before even fine lines have begun to appear. This “photoanti-aging” approach could be achieved with the use of very low incident levels of photon energy to stimulate the skin cells, both epidermal and dermal, at cell-specific wavelengths based on the photobiological findings of the literature over the past two decades or so, in order to increase their resistance to the effects of chronological and photoaging. Lasers and IPL systems could be used, but are extremely expensive and therapist-intensive. A new generation of light-emitting diodes (LEDs) has appeared as the result of a spin-off from the US NASA Space Medicine Program, which are much more powerful than the previous generation with quasimonochromatic outputs. These LEDs can offer target specificity to achieve photobiomodulated enhanced action potentials of the skin cells, in particular mast cells, macrophages, endotheliocytes, and fibroblasts, plus increases in local blood and lymphatic flow, in a noninvasive, athermal manner. New phototherapeutic LED-based systems have appeared to meet the need for a less-expensive but clinically useful light source to enable photoantiaging as a reality in clinical practice. Some studies proving the efficacy of LED therapy have already appeared, and based on their results LED therapy represents a potential new approach to prevention in anti-aging, so that further studies are warranted to prove its efficacy.

J Cosmet Laser Ther. 2005 Dec;7(3-4):196-200.

A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation.

Russell BA<>, Kellett N<>, Reilly LR<>.

Advanced Laser and Dermatologic Surgery Clinics PC, Beaverton, Oregon 97008, USA.

BACKGROUND: The use of visible or near infrared spectral light alone for the purpose of skin rejuvenation has been previously reported. A method of light emitting diode (LED) photo rejuvenation incorporating a combination of these wavelengths and thus compounding their distinct stimulation of cellular components is proposed.Objective. To assess the efficacy and local tolerability of combination light therapy in photo rejuvenation of facial skin. METHODS: Thirty-one subjects with facial rhytids received nine light therapy treatments using the Omnilux LED system. The treatments combined wavelengths of 633 nm and 830 nm with fluences of 126 J/cm(2) and 66 J/cm(2) respectively. Improvements to the skin surface were evaluated at weeks 9 and 12 by profilometry performed on periorbital casts. Additional outcome measures included assessments of clinical photography and patient satisfaction scores. RESULTS: Key profilometry results Sq, Sa, Sp and St showed significant differences at week 12 follow-up; 52% of subjects showed a 25%-50% improvement in photoaging scores by week 12; 81% of subjects reported a significant improvement in periorbital wrinkles on completion of follow-up. CONCLUSION: Omnilux combination red and near infrared LED therapy represents an effective and acceptable method of photo rejuvenation. Further study to optimize the parameters of treatment is required.

Dermatol Surg. 2005 Sep;31(9 Pt 2):1199-205.

Clinical experience with light-emitting diode (LED) photomodulation.

Weiss RA<>, McDaniel DH<>, Geronemus RG<>, Weiss MA<>, Beasley KL<>, Munavalli GM<>, Bellew SG<>.

Maryland Laser, Skin and Vein Institute, Hunt Valley, MD 21030, USA. rweiss@mdlaserskin-vein.com

BACKGROUND: Light-emitting diode (LED) photomodulation is a novel nonthermal technology used to modulate cellular activity with light. OBJECTIVE: We describe our experience over the last 2 years using 590 nm LED photomodulation within a dermatologic surgery environment. METHODS: Practical use of nonthermal light energy and emerging applications in 3,500 treatments delivered to 900 patients is detailed. RESULTS: LED photomodulation has been used alone for skin rejuvenation in over 300 patients but has been effective in augmentation of results in 600 patients receiving concomitant nonablative thermal and vascular treatments such as intense pulsed light, pulsed dye laser, KTP and infrared lasers, radiofrequency energy, and ablative lasers. CONCLUSION: LED photomodulation reverses signs of photoaging using a new nonthermal mechanism. The anti-inflammatory component of LED in combination with the cell regulatory component helps improve the outcome of other thermal-based rejuvenation treatments.

Di Yi Jun Yi Da Xue Xue Bao. 2005 Jan;25(1):109-10.

Effect of intense pulsed light on heat shock protein 70 expression in skin

[Article in Chinese]

Wang ML<>, Liu DL<>, Yuan Q<>.

Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China.

OBJECTIVE: To observe the effect of intense pulsed light (IPL) on heat shock protein 70 (HSP70) expression in skin and elucidate the biological mechanisms of photorejuvenation.

METHODS: The skin of 15 SD rats was exposed to IPL in 3 regions at the energy density of 34 J/cm(2) in triple pulses with the duration of 4, 5 and 6 ms, respectively, and pulse delays of 20 and 25 ms. On days 1, 3, 5, 7, 15 and 30 after treatment, specimens of the treated and untreated skin were taken, respectively, for determination of HSP70 expression by immunohistochemistry.

RESULTS: In treated regions, positive immunohistochemical staining was observed on day 1 in the epidermal keratinocytes, sebaceous gland cells and endothelial cells. The staining reached the highest intensity on day 7, gradually weakened on day 15, and disappeared on day 30. In the untreated areas, the cells were negative for immunohistochemical staining.

CONCLUSION: Skin HSP70 expression can be enhanced by IPL, suggesting the role of HSP70 in photorejuvenation.

Arch Facial Plast Surg. 2004 Nov-Dec;6(6):398-409.

Nonablative laser and light therapies for skin rejuvenation.

Kim KH<>, Geronemus RG<>.

Laser and Skin Surgery Center of New York, 317 E. 34th Street, New York, NY 10016, USA. Karen_hj_kim@hotmail.com

BACKGROUND: Multiple modalities have been described for skin rejuvenation, including ablative and nonablative therapies. Because of the prolonged recovery period associated with ablative procedures that injure the epidermis, nonablative skin treatments have grown increasingly popular. Various laser- and light-based systems have been designed or applied for promoting skin remodeling without damage to the epidermis.

METHODS: Studies investigating the use of nonablative procedures for facial rhytids or acne scarring with clinical, histological, and objective quantitative measurements are systematically reviewed.

RESULTS: Nonablative treatments are associated with clinical and objective improvements for the treatment of facial rhytids and acne scarring. Dermal remodeling seems to occur as a result of thermal injury, leading to dermal fibrosis without epidermal disruption.

CONCLUSIONS: Although results are not as impressive as those of ablative treatments, nonablative procedures are effective in the treatment of photoaging and acne scarring. As technology in nonablative therapies continues to evolve, future laser and light sources may yield even more favorable results.

J Drugs Dermatol. 2004 Nov-Dec;3(6):605-10.

A novel non-thermal non-ablative full panel LED photomodulation device for reversal of photoaging: digital microscopic and clinical results in various skin types.

Weiss RA<>, Weiss MA<>, Geronemus RG<>, McDaniel DH<>.

Maryland Laser Skin and Vein Institute, Hunt Valley, Maryland 21030, USA. rweiss@mdlaserkinvein.com

Photomodulation is a process that manipulates or regulates cell activity using light sources without thermal effect. Previous studies of LED photomodulation have shown skin textural improvement accompanied by increased collagen deposition with reduced MMP-1 (collagenase) activity in the papillary dermis. The purpose of this study was to investigate a separate cohort of patients (N =93) with a wide range of Fitzpatrick skin types treated by LED photomodulation using the Gentlewaves full panel 590 nm high energy LED array with a specific sequence or code of pulsing in the millisecond domain. Results showed improvement of signs of photoaging in 90%. The majority of patients demonstrated improvement in peri-ocular wrinkles, reduction in Fitzpatrick photoaging classification, global skin texture and background erythema, and pigmentation. No side effects were noted. LED photomodulation is a safe and effective non-painful non-ablative modality for improvement of photoaging.

Dermatol Surg. 2004 Aug;30(8):1085-90.

Intense pulsed light treatment of photoaged facial skin.

Kligman DE<>, Zhen Y<>.

SKIN, Inc., Conshohocken, Pennsylvania 19428, USA. skininc1@aol.com

BACKGROUND: It has been reported that intense pulsed light is efficacious for rejuvenation of photoaged skin, specifically the improvement of appearance of telangiectases and solar lentigines.

OBJECTIVE: The objective was to define the treatment variables for photodamaged facial skin using a newer intense pulsed light system.

METHODS: Twenty-three female subjects received three treatments using double-stacked pulses with fluences of 24 and 30 J/cm2. Response to treatment was evaluated using digital photography. Three signs of photoaging were evaluated: surface texture/roughness, mottled hyperpigmentation, and erythema/telangiectases.

RESULTS: There was a shift in clinical grading from more to less severe on all three measures of photoaging.

CONCLUSION: Intense pulsed light therapy was efficacious in ameliorating the clinical signs of photoaging. The device was well tolerated with minimal side effects.

Hautarzt. 2004 Jan;55(1):48-57

The excimer laser in dermatology and esthetic medicine

[Article in German]

Grema H<>, Raulin C<>.

Laserklinik Karlsruhe, Karlsruhe, Germany.

First reports about the use of the excimer laser in dermatology date back to 1997. It is seen as an improvement on conventional phototherapy and photochemotherapy because of the lower cumulative UV-dose involved, the shorter time frame required for treatment and the option of targeting individual lesions without affecting the surrounding healthy skin. In addition to the indications of psoriasis vulgaris, vitiligo and atopic eczema (for which there is now FDA approval in the US), the spectrum of possible uses for the excimer laser is growing rapidly, especially in the field of light-sensitive dermatoses. Case studies so far have ranged from post-operative hypopigmentation to acne vulgaris and from alopecia areata to parapsoriasis en plaque. The foremost priorities in the future will be to evaluate reproducible therapeutic regimens with realistic prospects of success in large-scale studies; assess potential iatrogenic risks in treatment; develop pathogenetic models for the mechanism of action; and define therapeutic approaches to new indications. This paper summarizes the publications to date and discusses our observations and experiences.

J Cosmet Laser Ther. 2003 Dec;5(3-4):168-74.

Long-term clinical results of IPL photorejuvenation.

Brazil J<>, Owens P<>.

Olympic Dermatology and Laser Clinic, 424 Lilly Road NE, Suite A, Olympia, WA 98516, USA.

BACKGROUND: Non-ablative photorejuvenation is characterized by the reduction of intrinsic and extrinsic changes in photodamaged skin. Only short-term improvement has been documented previously.

OBJECTIVE: To evaluate quantitatively the short-term and long-term clinical effectiveness of multiple full-face IPL treatments for non-ablative facial photorejuvenation.

METHODS: A total of 47 patients with varying degrees of photodamaged skin and rosaceal dermatitis underwent a series of four to five IPL treatments with a Vasculight (Lumenis Corp). Treatments were conducted every 3-4 weeks. Photographs were taken at baseline and after the treatment series was completed at both 6 weeks and 6 months. Adverse effects and clinical improvement were documented. A patient satisfaction questionnaire was completed and reviewed at the 6-month evaluation period.

RESULTS: Standardized evaluation of rhytids showed a statistically significant improvement in wrinkles at both evaluation endpoints. Some degradation occurred over time. Facial vascularity, dyschromia, and large pore size progressively improved from the 6-week measurement to the 6-month measurement.

CONCLUSION: This clinical study demonstrates that non-ablative facial rejuvenation is associated with long-term clinical improvement of facial rhytids, abnormal vascularity and pigmentary disorders with minimal risks and side effects to the patient.

Curr Opin Ophthalmol. 2003 Oct;14(5):246-52.

Facial skin rejuvenation.

Holck DE<>, Ng JD<>.

Wilford Hall Medical Center, San Antonio, Texas, USA. David.Holck@LACKLAND.AF.MIL

PURPOSE OF REVIEW: In recent years, many new products and techniques have arisen that are useful in the rejuvenation of facial skin. Most of the therapies are directed at improving the results of photoaging. These cutaneous changes occur from chronic exposure to ultraviolet B light (290 to 320 nm) associated with sunburn, and ultraviolet AII light (320 to 340 nm), and ultraviolet AI light (340 to 400 nm) associated with photoaging. Clinically chronic photoaging may result in fine wrinkles, texture abnormalities, pigment dyschromias, and actinic keratoses.

RECENT FINDINGS: Many methods of patient assessment are available, but the most useful include the Fitzpatrick skin type classification and the Glogau photoaging scale. Although many therapies are available to reduce or even reverse many of these aging changes, patient education regarding lifestyle changes (especially smoking cessation) and sun avoidance need to be a critical foundation of treatment. Indeed, patient participation in their own skin care regimen is important for any program to be effective. Topical therapy including tretinoins, hydroxy acids, bleaching agents, and sunscreens are discussed herein.

SUMMARY: The physician has an important role in understanding which treatment options are appropriate for mild, moderate, and severe photoaging, and in educating patients on the risks and benefits of each. This includes resurfacing modalities with microdermabrasion, chemical peels, and laser skin resurfacing.

LOW LEVEL LAESR THERAPY IN DERMATOLOGY: AN OVERVIEW OF THERAPEUTIC POSSIBILITIES

1Zlatko Simunovic, M.D., F.M.H., 2Tatjana Trobonjaca, M.D.

1Pain Clinic-Laser Center, Locarno, Switzerland 2Laser Center, Opatija, Croatia

The first application of Low Level Laser Therapy (LLLT) was completed on dermatological disorders like skin ulcers, in early sixties. In the meantime, dermatological indications for LLLT have increased. Particular effects of LLLT are observed when laser beam is applied on the open wound, which healing can be significantly accelerated especially in patients with delayed or impeded wound healing like patients with circulatory disorders, diabetic patients, etc. LLLT triggers biostimulative-regenerative processes inside the cell and subsequently causes revitalisation of the issue as well. Second effect of LLLT refers to the vasodilatation and neovascularisation of local blood and lymph vessels, thus causing a better removal of waste products and, on the other hand, improved oxygenation and nutrition of damaged tissue. Analgesic and anti-inflammatory effects of LLLT are also significant when irradiating certain dermatological changes. All effects mentioned before will be discussed in details during the lecture. Therefore, LLLT is used today in dermatology in the treatment of the following conditions: – Ulcus cruris – Burns – Herpers infections – Scar tissue – Keliod – Sclerodermia – Rosacea – Neurodermitis – Eczema – Lichen ruber planus and scrofulosus – Psoriasis – Haemathoma – Etc. Each pathological condition will be explained, and optimal and individual energy densities will be presented in this lecture.

AESTHETIC TREATMENTS WITH LOW LEVEL LASER THERAPY

1Tatjana Trobonjaca, M.D., 2Zlatko Simunovic, M.D., F.M.H.

1Laser Center, Opatija , Croatia 2Pain Clinic-Laser Center, Locarno, Switzerland

If taking into the consideration the list of aesthetic disorders which can be treated with either Low Level Laser Therapy (LLLT) or surgical lasers, it is justified to say that laser is also the light of beauty. Although its first applications were focussed on serious diseases like skin ulcers and painful conditions, employment of LLLT in aesthetics has initiated in mid seventies. Aesthetic changes are mainly benign and they won’t seriously damage the health state of patient’s body, but aesthetic problems are strictly subjective and the same problem causes different psychological reaction in different persons. Development in modern medicine and technology brought many new techniques and devices, which are successfully used in aesthetics today. Laser is one of the highlights in aesthetics today where it is applied mostly for facial rejuvenation, because the face is psychologically the most sensitive aesthetic area of each person. Facial rejuvenation can be achieved with surgical lasers, which remove superficial layer of atrophic skin, leaving that area to be self- regenerated. It is an invasive method, while the process of regeneration can last few weeks even months, with a prohibition of disposing to the sunlight. On the other hand, skin rejuvenation can be completed with use of LLLT or athermal lasers like HeliumNeon (HeNe) or infrared (IR). The first one is mostly applied in the treatment of superficial changes, while the IR laser is used for irradiation of deeper structures. LLLT obtains good results in aesthetics due to its three main effects: biostimulative-regenerative, analgesic and anti-inflammatory effect, which will be presented in this lecture. LLLT can be applied in aesthetics like monotherapy or complementary treatment modality to the topic medications. Frequent indications for LLLT in aesthetics are as follows: – Acne – Cellulite – Striae – Alopecia – Wrinkles – Lentigo senile This lecture will cover all relevant details related to LLLT and each condition, with application techniques and recommended individual optimal energy densities.

Used by the kind permission of the Czech Society for the Use of Laser in Medicine, www.laserpartner.org<>

Soft Laser in Cosmetics

Laser Partner, 11.3.2003

Marta Moidlova, M.D., Clinic for laser and esthetic dermatology and plastic surgery, Old Town Square, Prague, CZ

Premysl Fryda, MediCom a.s. Laser

E-mail: moidlova@moidlova.cz<>

Abstract

Cosmetics is a well established and independent branch, apparently different from plastic surgery, esthetic dermatology and similar medical specialties, yet complementing them very effectively. However, is there any difference between individual beauty parlors? Definitely there is, but where? Enthusiasm, knowledge, experience, talents, good eyes and clever fingers – this is an absolute minimum in terms of a cosmetician`s “software”. Speaking about “hardware”, a good cosmetician needs a suitable place for the business, a chair, a table, a mirror … all the same. Then cosmetic milks, creams, masks, agents, all the beatiful jars, sprays and cups come … they all have them, too. So where is the difference, if any at all? The difference lies in modern technical equipment, in technical devices helping a cosmetician be more efficient, more successful, more up-to-date, and, first of all, more attractive for the clients. And here, undoubtedly, laser dominates.

Technical gadgets

Speaking about technical equipment, what options can a cosmetician have? Not many, really:

  • Electrolytic epilator, though it is a bit an obsolete technique, a time consuming one, painful, unprecise, with imperfect results, and in case of electrocauter successive scarring may appear.
  • Vacuum lymphodreinage unit, though this technique comes much more under medical specialists, especially as one of the means of consecutive treatment after oncological surgeries.
  • Solarium – only a supplement from the point of view of cosmetics.
  • Microdermabrasion seems an ideal option. It is capable of scraping off superficial layers of dead skin cells from the face, décolté, hands etc. with a flow of tiny crystals. Microdermabrasion is a great tool in hands of an experienced cosmetician, eliminating fine wrinkles, acne scarring, minor pigmented lesions, rough skin and the like. The skin gets regenerated, smoothened and cleansed, not only the skin looks better, but is also able to take in cosmetic preparations much better in the course of successive treatment.
  • Polarized biolamps are also a possibility how to improve cosmetic treatments and care. However, we should avoid using monochromatic devices using different color filters or sources, for those only deprive us of the synergic effect of polychromatic light devices enabling the light to penetrate in different depths in tissue. A separate article on the use of biolamps in cosmetics was published in Laser Partner Clinixperience No. 45/2002.
  • Laser is the real king of cosmetics. Surgical laser is able to ablate wrinkles, repair scars, remove pigmented lesions and age or sun spots, rid of unwanted tattoos and hairs. Some of the applications do not even have a non-laser alternative, such as permanent hair removal or elimination of  naevi flamei. All the above mentioned applications, and many others, can only be performed with a surgical laser and by physitians. However, apart from those, there is another group of lasers, called soft lasers (a name very appropriate for cosmetics), or therapeutic, biostimulation, low-level lasers (low-level laser therapy – LLLT), and those will be the subject of this article.

Mechanisms of soft lasers

Laser is nothing else but light with specific features, and it is generally known that for every living cell light is of fundamental and unsubstitutable importance. This phenomenon can be noticeable best in plants assimilating light to be able to grow, however similar dependency applies to animal organisms, too. Lack of light causes growth disorders and can also result in psychic defects, depressions, or even in a specific disease called seasonal light deficiency.

Laser energy is absorbed in tissue through cytochrome cells, mitochondrial apparatus of individual cells transforming light energy into cellular energy. At the same time, passage of light improves permeability of cellular membranes, leading to their better nutrition, improved function and quicker cell division. These processes in tissue activate macrophages (responsible for absorption of  noxious agents and support of healing processes), improve activity of fibroblasts (mast cells supporting collagen synthesis in tissue), and support improved production of specific enzymes. Apart from stimulation of growth and wound healing medicine can also make use of other characteristics of laser beam, such as ability to decrease pain through influencing neural peripheries, anfi-inflammatory effect, or stimulation of acupuncture points or physiological trigger points.

In cosmetics it is very important to choose a suitable laser device. The first decission to make is an appropriate wavelength of emitted light, i.e. its color. The rule is that red color (632 – 670 nanometers – nm) is convenient for superficial applications, not penetrating deep in tissue and thus all energy being absorbed in the skin and subcutis. On the other hand, infrared (IR) lasers with higher penetration depths are quite useless in cosmetics, whilst they come in very useful in massage and physiotherapy facilities . The second important value is the power output of a laser, which should be for cosmetics within the range of 10 to 40 miliwatt (mW). Lower output leads to excessive prolongation of application times necessary to irradiate recommended dosages of energy, and, on the other hand, suitable red lasers with higher output are usually very expensive. The third important issue to decide on is the construction of lasing device. You can buy a laser with a hand-held pinpoint laser probe, which will be suitable especially when treating little lesions (See Fig 1). On the other hand, when working on larger areas (whole face, décolté etc.), you might prefer a laser scanner automatically distributing light on required area and freeing your hands for another client (See Fig. 2). A laser with automatically adjusted parameters of therapy is recommended.

Figure 1: Treatment with a laser probe Figure 2: Laser scanner

Soft laser in cosmetics

LLLT has many possible applications in cosmetics and laser can even lay the foundations of a specialized beauty salon. The following list has originated on the basis of years of experience, and can provide readers with a general overview of potentials of this useful and profitable method.

1)    Healing of inflammatory and other pathologies

  • Acne – one of the most frequent cosmetic problems, due to civilization impacts shifting more and more into middle age. Laser helps effective healing of papuli and pustuli even after a few applications, in most cases skin responding to laser treatment spontaneously and very quickly.
  • Alopecia – supportive treatment of alopecias, hair growth stimulation and improvement of quality.
  • Dermatitis – LLLT helps to improve inflammatory and other conditions on the skin.
  • Eczema – laser can improve quality of life of the patients by diminishing some of the superficial manifestations of the disease.
  • Herpes – one of the most effective applications. A herpes usually does not even appear if the painful spot is irradiated before eruption, or has a relatively mild symptoms. In other cases a scab can be expected to create on the herpes within a few hours after irradiation, avoiding unpleasant long lasting suppurative manifestations. LLLT shortens healing by more than fifty per cent, and is also suitable to treat post-herpetic neuralgia.

2)    Post-procedure applications

  • Healing of nail matrices – successful treatment also after nail design applications.
  • Post cleansing treatment – quicker regeneration of skin suffering from red spots, minor edemas and haematomas, open and widened pores.
  • Post epilation treatment – application of LLLT after wax or electric epilation significantly soothes irritated skin, healing up punctures in rather a short time. It is recommended to stimulate the area to be treated not only after the application, but also before the initial hair removal, due to analgetic effect of laser light, as well as due to more effective start up of healing processes.
  • Permanent make-up – after mechanical penetration of pigments under the skin LLLT regenerates microscars, soothing irritated skin.

3)    Scars management

  • Post acne scarring – a long term treatment helps to improve the final condition.
  • Scars – LLLT contributes to decolorization, smoothening and softening scars.
  • Striae – regeneration of unwanted microscars and rhagadae in skin.

4)    Improving the beauty of your clients

  • Biostimulation of skin – overall soothing of the skin, improvement of its look, LLLT smothens and stretches the skin removing its minor defects.
  • Cellulitis – laser should be understood as one of the components of comprehensive treatment, LLLT improving microcirculation of lymph and blood, locally decreasing the feeling of pressure and pain, releasing collagen threads.
  • Dandruff – LLLT can help in combination with special anti-dandruff shampoos.
  • Laser Mask (Le Masque de Laser) – application of a face mask, the performance of which is activated by irradiation with a laser beam, a combination of deep cleansing of tissue with biostimulation.
  • Rejuvenation – improving the looks, smoothening and tightening of the skin.
  • Wrinkles – soft laser is not able to rid of the wrinkles mechanically, however by improving the condition of the skin it contributes to its increased flexibility and elasticity.

5)    Other cosmetic-related applications

  • Chronic Fatigue Syndrome – thanks to its stimulative effects LLLT may become a part of comprehensive treament.
  • Seasonal Light Deficiency (SLD) – application on epiphysis has been described as a means of suitable psychostimulation.
  • Migraine – relief of negative manifestations of similar diseases may sometimes also be required.
  • Myorelaxation – beauty parlors are sometimes associated with massage or fitness facilities where LLLT can be used to decrease muscle spasms prior to initial massages, or to release tension in case of neck and lower back pain.  

Hygienic conditions for soft laser in cosmetics

It is generally believed that soft laser can be operated only by physicians, however this is not a correct opinion. Soft lasers can be commonly operating in, and their advantages can be made use of by, beauty parlors, haidressers salons, massage and regeneration facilities and the like, provided their users observing specific hygienic and safety regulations.

The first prerequisite is a proper training, familiarizing the staff with performance and mechanism of laser in living organism, with possibilities of indications and applications, with initial laser techniques, as well as with contra-indications and labor safety. A laser workplace must be adapted in such a way that an unwanted laser beam cannot hit anybody, all windows and mirrors must be covered by jalousie or curtains not transmitting laser light during laser operation. Corresponding laser safety eyewear is also required. Every laser workplace is subject to hygienic control classification.

Current medical legislation imposes a certain limitations on cosmeticians regardless to whether they work with laser or not. They must not break integrity of the skin, must not perform procedures on sick skin or mucosa, and must not manipulate scars and birthmarks. In fact most of beauty centers either co-laborate with doctors or work under direct supervision of medical specialists who can guarantee expert skin care in full extent. However, even within the frameworks of limited number of procedures, soft laser represents a reliable, effective, and attractive skin care.

Related articles

  • Laser Partner No. 23/2001: P. Petrovska: Laser in dermatology
  • Laser Partner No. 25/2001: T. Trobonjaca, Zlatko Simunovic: Aesthetic treatments with low level laser therapy
  • Laser Partner No. 33/2001: R. Smucler et al.: Laser Mask increasing the potential of laser biostimulation in cosmetology and dermatology
  • Laser Partner No. 45/2002: Bozena Apetaurova: Biolamp in cosmetic practice

Literature

  • Jan Javurek: Fototerapie biolaserem – lecebna metoda budoucnosti, Grada Publishing, Praha 1995
  • Zlatko Simunovic a kol.: Lasers in Medicine and Dentistry, Vitagraf Rijeka, 2000
  • Jan Tunér, Lars Hode: Laser Therapy – Clinical Practice and Scientific Background, Prima Books, Grangersberg 2002
Skin Therapy Lett. 2003 Apr-May;8(4):4-7.  

 

Nonablative laser and light therapy: an approach to patient and device selection.

Alam M, Dover JS.

Section of Cutaneous and Aesthetic Surgery, Department of Dermatology, Northwestern University, Chicago, IL, USA.

Nonablative laser and light therapy is a relatively novel modality for the improvement of the visual appearance of photodamaged, scarred, and injured skin. A number of different wavelengths and devices have been purported to be efficacious for the delivery of nonablative therapy. Among the features that can be addressed are red spots and telangiectasia, pigmentation and lentigines, and their daily routines while benefiting from the cumulative effects of skin rejuvenation.

Dermatol Surg. 2002 Dec;28(12):1115-9.

Rejuvenation of photoaged skin: 5 years results with intense pulsed light of the face, neck, and chest.

Weiss RA<>, Weiss MA<>, Beasley KL<>.

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. rwderm@earthlink.net

BACKGROUND: Photorejuvenation involves the use of lasers or light sources to reverse signs of photoaging. Multiple devices have been shown to be effective over the short-term. OBJECTIVE: To investigate the long-term clinical results on the face, neck and chest at 4 years using filtered flashlamp intense pulsed light (IPL) for treatment of photoaging changes of telangiectasias, dyspigmentation, and rough skin texture.

METHODS: A chart review of 80 randomly selected patients with skin types I-IV who were treated by IPL during 1996 and 1997 was performed. Photos and patient self-assessment were graded for features of textural smoothness, telangiectasia severity, and blotchy pigmentation into four categories of worse, no change, slightly better (less than 50% improvement) and much better (greater than 50% improvement).

RESULTS: At 4 years following initial treatment, skin textural improvement was noted in 83% of the subjects. Telangiectasias were improved in 82% of subjects, while pigmentation remained improved in 79%. The median number of treatments was 3. The face responded slightly better than the chest or neck. Most common side-effects included temporary mild crusting (19%), erythema (15%) and purpura (6%).

CONCLUSION: Signs of photoaging including telangiectasias and mottled pigmentation of the face, neck, and chest, can be improved by IPL with a long-lasting result. Minimal or no downtime with minimal adverse effects can be achieved with the settings reported. Skin textural smoothing, although not easily quantified, is an additional benefit observed long-term.

Laser Surg Med. Abstract issue, 2002, abstract 242.

The effects of adding low energy laser irradiation after skin resurfacing in lowering complication.

 Fereydson E, Samieh M.

Laser therapy is a valuable supportive therapy after skin resurfacing with CO2 laser. In a study by Fereydson. twenty patients had full face skin resurfacing with superpulse CO2 laser, 500 mJ/cm2. Ten patients had additional 780 nm laser therapy. This additional therapy lowered complications such as pain, erythema, infection rate and itching.

Dermatol Surg. 2002 Dec;28(12):1115-9.

Rejuvenation of photoaged skin: 5 years results with intense pulsed light of the face, neck, and chest.

Weiss RA<>, Weiss MA<>, Beasley KL<>.

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. rwderm@earthlink.net

BACKGROUND: Photorejuvenation involves the use of lasers or light sources to reverse signs of photoaging. Multiple devices have been shown to be effective over the short-term.

OBJECTIVE: To investigate the long-term clinical results on the face, neck and chest at 4 years using filtered flashlamp intense pulsed light (IPL) for treatment of photoaging changes of telangiectasias, dyspigmentation, and rough skin texture.

METHODS: A chart review of 80 randomly selected patients with skin types I-IV who were treated by IPL during 1996 and 1997 was performed. Photos and patient self-assessment were graded for features of textural smoothness, telangiectasia severity, and blotchy pigmentation into four categories of worse, no change, slightly better (less than 50% improvement) and much better (greater than 50% improvement).

RESULTS: At 4 years following initial treatment, skin textural improvement was noted in 83% of the subjects. Telangiectasias were improved in 82% of subjects, while pigmentation remained improved in 79%. The median number of treatments was 3. The face responded slightly better than the chest or neck. Most common side-effects included temporary mild crusting (19%), erythema (15%) and purpura (6%).

CONCLUSION: Signs of photoaging including telangiectasias and mottled pigmentation of the face, neck, and chest, can be improved by IPL with a long-lasting result. Minimal or no downtime with minimal adverse effects can be achieved with the settings reported. Skin textural smoothing, although not easily quantified, is an additional benefit observed long-term.

Semin Cutan Med Surg. 2002 Dec;21(4):280-7.  

 

Intense pulsed-light photorejuvenation.

Sadick NS, Weiss R.

Department of Dermatology, Weill Medical College of Cornell University, New York, NY, USA. nssderm@sadickdermatology.com<>

Intense pulsed light photorejuvenation represents a novel mode of treatment of photodamaged skin. A broad-spectrum flashlamp (500-1200 nm) targets chromophores reversing pigmentation, vascular and pilosebaceous aberrations. Both cytokine mediated as well as thermally induced deep dermal remodeling may be achieved using the varied polychromatic wavelengths associated with this technology. Inflammatory dermatosis such as rosacea may also be addressed as well. A structural approach to non-ablative rejuvenation utilizing intense pulsed light is associated with high patient satisfaction and minimal adverse sequelae.

Semin Cutan Med Surg. 2002 Dec;21(4):251-65.  
   

Biophysics of nonablative dermal remodeling

Ross EV, Zelickson BD.

Dermatology Department, Naval Medical Center San Diego, San Diego, CA 92134, USA. vicross@mfn.com<>

This article explores the physics of nonablative skin remodeling as well as the histologic sequelae. Although there have been several studies of nonablative skin remodeling, the exact mechanisms of action and thus the optimum device-specific parameters are not yet known. The article is divided into a discussion of the physics of laser-tissue interactions, followed by a review of the types of devices used for nonablative skin remodeling, and the histologic findings that follow treatment.

Hautarzt. 2002 Jun;53(6):385-92.  

“Skin rejuvenation” by non-ablative laser and light systems: Literature research and overview

[Article in German]

Grema H, Raulin C, Greve B.

Laserklinik Karlsruhe, Kaiserstrasse 104, 76133 Karlsruhe.

Currently, ablative laser therapy (with CO2/Er:YAG lasers) and deep chemical peeling are effective and promising methods of skin rejuvenation. The induction of collagen synthesis was observed after peelings with trichloroacetic acid or phenol as well as after treatments with the CO2 laser. In past years, the undesirable side effects and risks of these methods have led to intensified research in the fields of non-ablative facial rejuvenation and subsurfacing by means of ablative laser systems and intense pulsed light systems. The objective is to achieve selective, heat-induced denaturalisation of dermal collagen that leads to subsequent reactive synthesis but does not damage the epidermis. Recently, the results of numerous clinical and histological studies have indicated that these new technologies are successful. After critical review and assessment of current literature, we can say that in terms of their efficacy, non-ablative methods are not a comparable alternative to ablative skin resurfacing.

Used by permission of the Czech Society for the Use of Laser in Medicine, www.laserpartner.org<>

Biolamp in Cosmetic Practice

Laser Partner, 3.4.2002

Bozena Apetaurova, M. D., Ph. D.

Abstract

The paper of now deceased author deals with the use of polarized Biolamp in everyday cosmetic practice. It stemms from theoretical bases of effects of polarized light on various wavelengths on the skin and describes its general influence on metabolism and microcirculation in the tissue. Biolamp is an effective tool in treating acne, seborrhoic eczema, alopecias, herpes, wounds, ulcera, and in regenerating aging skin. Although all these complaints are primarily indicated for a therapeutic laser (LLLT), especially in extensive and serious cases, Biolamp has proven itself a successful complement of LLLT, or in minor cases even a simpler and inexpensive alternative of LLLT.

The Effects of Light

Cosmetics is a branch encompassing both prevention and therapy of skin diseases. It consists of skin cleansing, massages, the use of cosmetic agents and preparations and, last but not least, phototherapy with Biolamp as one of its forms.

Sun rays touching the Earth include in its spectrum parts with wavelenghs roughly between 300 to 4000 nanometres (nm). The band of visible light reaches from circa 430 to 750 nm. Shorter wavelengths mean ultraviolet light, whilst infrared (IR) light is emitted on longer wavelengths. Human body is used to these wavelengths.

Human organism in general, and human skin in particular react to irradiation within these wavelengths in different ways, often very selectively in rather a narrow frequency band, and this has been utilized in applications of  therapeutic as well as of surgical lasers in cosmetics. In general we can say that the skin is relatively pervious for light irradiation between 300 and 1100 nm, thus this irradiation can penetrate the skin rather deep. Longer bands of IR irradiation with wavelengths longer than 1300 nm are absorbed well in the skin, this becomming evident in increasing the temperature of the skin.

Under excessive exposures ultraviolet light has generally mutagenic and cancerogenic effects and it is necesary to consider it harmful.

Irradiation in the shorter IR band of the spectrum within 750 – 1100 nm wavelengths is the main resource of energy for plants and some types of bacteria in the nature and, according to literature (1) it may also be a source of energy for cells of human organism.

Positive effects of light irradiation on treatment and healing of skin has been known for a long time. However, the knowledge of effects of its individual spectral parts and of its characteristics (polarization, for instance) has deepened only in the course of the last few decades, so that it might be possible to make the best of it for rational treatment, especially when modern technical means, such as Biolamp or a therapeutic laser, are so easily accessible.

Biolamp emits light in spectral range 430 – 2800 nm. Its light does not contain any ultraviolet, nor significant heat infrared parts. Light within the range of  750 to 1200 nm, i.e. in the range where human body cells are able to transform the energy of light radiation into cellular energy, is the most intensive. This, as well as other, not so very well known, effects of light irradiation have a positive effect on the skin.

In general, it is possible to state that thanks to this particular light energy cellular metabolism is improved and oxidation processes in cells intensified, both resulting in possible regeneration of damaged cells as well as in strengthening of healthy cells. Through improved oxidation of the tissue its resistence to infections is strengthened. Furthermore, division of fibroblasts, of which ligamentary cells diferenciate, is influenced positively as well as metabolism of collagen filaments is improved, as far as their production in the event of deficiency is concerned. Blood microcirculation, favouring quick resorption of oedemas in damaged tissues, is positively influenced, too.

Biolamp emits polarized light. Polarization is believed to improve mentioned positive effects, although photobiological basis of this mechanism has not yet been fully revealed.

Biolamp irradiation has generally biostimulative, anti-inflammatory, and regeneration effects on skin, and these can be advantageously utilized for a complimentary treatment in a cosmetic practice.

Treatment of Acne with Biolamp

One of the most frequent dermatoses is represented by acne. It affects cheeks, forehead, shoulders, back and chest. Unsightly look of the skin causes patients depressions, bringing often also psychic problems. It has been till today a grave therapeutic problem for cosmeticians as well as for physicians.

Acne is a chronic inflammatory affection, damaging a pilosebaceous unit multifactorially. Hyperkeratinization and obstructions of sebaceous follicles appear. Increased level of androgenes stimulates increase of production of sebum and multiplication of bacterial flora, particularly of Propionibacterium Acnes, causing successive inflammatory manifestations.

Primarily, clinical image of acne includes comedones. Furthermore, there appear papulae, papulocysts, cysts, apostemas, conglobates, and indurations.

Acne is classified according to the scope of affection. For cosmetic purposes it is usually suitable to distinguish between primary acne without inflammatory symptomas, and secondary acne accompanied by inflammatory manifestations, or between superficial and deep acne. Strategy of treatment and prognosis of the disease is determined according to the scope of involvement. There is a rule to begin the treatment as soon as possible, even though extent and clinical symptoms may appear only minor, for further complications and progression of the ailment can only hardly be foreseen.

Therapy should be approached comprehensively, and we should make full use of all diagnostic resources in order to be able to determine individually the best suitable treatment. Therapy requires good cooperation between therapist and patient, strictly observing dietary and hygienic regimes, as well as regular and thorough treating and cleansing of the skin at home.

Rational treatment is aimed at the overwhelming phenomenon. In fact it means to be concentrated on decrease of formation of comedones, suppression of creation of sebum, positive influence on bacterial flora, and quicker healing. Therapy can be either fully external, or externally-internal utilizing antibiotics, hormonal therapy, corticosteroids, retinoids etc. (3, 4, 5)

For a cosmetic care treatment of only superficial forms of acne with no major purulent affections is appropriate. In case of even minor inflammatory finding consulting a physitian-specialist is recommended.

Regular mechanical cleansing of affected spots on the skin holds a significant role in treatment of acne. Expertly thorough and gentle cleansing is the basic prerequisite of  successful healing of acne (Editor: incl. among others deep cleansing of skin using the Laser Mask – see Laser Partner Clinixperience No. 33).

Agents utilized in cosmetic practice represent a broad and rich spectrum, however these are not subject matter of this paper. High hygienic care, as well as due choice of these agents should be paid attention to. We recommend using natural agents with no irritating conservatives and perfumes.

Treating deeper forms acne we shall change the strategy complementing standard external treatment by internal medication, based on long-term administration of antibiotics, hormonal preparations, corticoids etc. Regular monitoring of both clinical and laboratory values is necessary in these cases, due to possible side effects of these drugs on the organism.

The main effort in treatment of acne is always to use all possible non-invasive means to treat affected skin and to keep the skin in a good condition. One of these means is phototherapy and therefore I am now going to describe my good experience in using Biolamp.

In the course of twelve months I was treating total 47 patients with problematic acne affected skin, 39 women and 8 men. The youngest member of the group was a girl at the age of 13 years, the eldest was a 47 years old woman. Average age of the group was 26.6 years.

In all the cases I was proceeding in the same method, consisting of cleansing of the skin a using special foments and masks. Furthermore, a strict regimen and skin care products were recommended for home care. Cosmetic agents were pure natural, and were not changed for the whole period of following the patients. Biolamp was applied as a complementary means of treatment.

At the beginning of treatment of mentioned patients Biolamp was used as often as possible. It was applied on duly cleansed skin for the period of 5 minutes, at least 10 to 15 times, for 3 to 5 weeks. Following applications were changed according to results obtained. I consider this number of applications significant, for noticeable improvement occured after 3 to 5 irradiations at the earliest. Interruption for a longer time lead to relapses.

This gusty start has appeared necessary to obtain a good therapeutic effect. Best results were achieved when a patient having purchased a Biolamp applied it at home for about 3 minutes 3 times a day. In all the cases after such a therapy a great improvement was noticed, followed even by a complete heal-up in cases of a minor inflammatory finding.

Tactics of further time applications of Biolamp was directed by local findings. I usually applied Biolamp in once-a-week to once-a-month periods, for the whole time of further monitoring.

Majority of patients had noticed themselves aggravation of acne manifestations in certain periods (before menstruation, after viroses, after taking certain drugs etc.) and therefore made preventive visits during these risky periods in order to take more frequent irradiations with Biolamp in order to avoid, or even totally supress such a deterioration.

Other Cosmetic Applications of Biolamp

During a systematic one-year following of effects of Biolamp on acne-affected impure skin there was also a possibility to monitor its effects on other skin affections, simultaneously occuring in the patients. I am going to mention those with a noticeable positive effect of Biolamp irradiation.

So called seborrhoic eczema appears usually on the forehead at the borderline between skin and hairy part of head, being manifested by exfoliating itchy skin. However, it often affects the whole scalp. Exfoliation is sometimes markedly suggestive of dandruff. Greasy hair and its excessive defluvium are rather a rule. After application of Bioplamp on the face with the light spot reaching up over the forehead the condition improved remarkably. That was why I extended in these patients irradiation with Biolamp to the hairy scalp, too.

However, positive effects were obtained also against excessive hair loss after ilnesses, stress, drugs medication (especially antibiotics) etc.

On atopic eczema application of Biolamp was also a benefit upon standard dermatology treatment, according to professor Novotny`s statement. (2)

After a long term application of Biolamp I noticed significant regeneration changes, especially on older skin. Skin became smoother with wrinkles less noticeable, with a nice healthy look. I also achieved minor scars after secondary healing of acne getting smoothed away on different levels. I use Biolamp as a part of a complex cosmetologic care of aging skin.

Furthermore, very good results on herpes labialis vere recorded. Application of Biolamp for about 5 – 6 minutes twice a day in the very initial stage of the disease caused almost immediate halt of further progression. Herpes dried quickly without recrement.

I also have to mention good results in healing fresh wounds and on early phlogistic processes on the skin, as well as on varicose ulcers.

Conclusion

It is necessary to stress that Biolamp is no panacea. Biolamp should be regarded as an effective supportive treatment complementing standard methods and comprehensive skin care, if applied in suitable frequency and reasonable dosages. However, it should be mentioned that its effect appears after a longer application and thus an immediate success cannot be expected.

In the course of my monitoring I could not use a control group due to obvious reasons, for each patient has the right for all accessible means to be used on him/her in order for the best possible results be achieved in the shortest possible time. Therefore evaluation of results must obviously be subjective, being based  not only on my findings, but also on reactions of my patients. The evaluation is unambiguously positive.

In cases of larger and substantial afflictions, deep scars and other diseases of the skin obviously treatment with a laser (LLLT) is recommended. Complementary and simple irradiation with Biolamp also proved successful, since results obtained by laser therapy can be stimulated and confirmed with no further progression of the disease.

Last but not least, using Biolamp is very simple, safe, and not requiring special precautions, meaning a great advantage not only for a cosmetic practice but also for its home use.

Literature

  1. Warnke, U. W.: Wie Licht-Energie zu Zell-Energie wird. Arztliche Praxis, Jhg. 97, pp. 3039-3040, 1987.
  2. Novotný, F.: Ekzémové onemocn?ní v praxi (Eczematic Diseases in Practice). Grada, Avicenum, 1993.
  3. Hegyi, E., Kolibášová, K.: Stratégia výberu lie?ebných metód v terapii acne vulgaris (Strategy of Choosing Therapeutic Methods in Therapy of Acne Vulgaris). 1/4 s. Derm. 67, 1992, Nr. 5, pp. 281-284.
  4. Rasochová, E.: Akné – plehlad sú?asných možností liecenia (Acne – a Review of Contemporary Possibilities of Therapy). Slovenský lekár, 1992, pp. 18-21.
  5. Poláchová, I.: On Treating Acne Vulgaris with Antiandrogens. Acta Universitatis Palackianae Olomucensis, 1991, Tom. 129 Facultatis Medicae, pp. 133-137.

Dermatol Surg. 2001 Jul;27(7):627-31; discussion 632.

Photorejuvenation for Asian skin by intense pulsed light.

Negishi K<>, Tezuka Y<>, Kushikata N<>, Wakamatsu S<>.

Department of Plastic and Reconstructive Surgery, Tokyo Women’s Medical University, Daini Hospital, Tokyo, Japan.

BACKGROUND: Dermabrasion and deep chemical peeling are used in the treatment of photoaged skin. These ablative procedures are effective enough to produce a certain improvement but have often caused postinflammatory hyperpigmentation among Asian patients. To avoid such adverse effects, a new, nonablative procedure has been sought. OBJECTIVE: To determine the effectiveness of photorejuvenation for Asian skin using intense pulsed light (IPL). The specific parameters used, improvement ratios, side-effects, and downtime required are also discussed. METHODS: Ninety-seven patients were treated for photoaging using IPL. The cutoff filters of 550 nm and 570 nm were utilized for three to six treatments at intervals of 2 to 3 weeks. RESULTS: Treatment results were evaluated and rated by both patients and physicians at the end of the third treatment based on improvement in pigmentation, telangiectasia, and skin texture. A combined rating of “good” or “excellent” was given to more than 90% of the patients for pigmentation, more than 83% for telangiectasia, and more than 65% for skin texture. There were some minor complications in four cases: one had erythema that continued to the next day and three had minor blisters leaving no marks. CONCLUSION: Photorejuvenation using IPL is a completely safe and effective procedure even for Asian skin. It will be increasingly used for skin rejuvenation in the future.

Dermatol Surg. 2000 Sep;26(9):835-42; discussion 843.

Noninvasive rejuvenation of photodamaged skin using serial, full-face intense pulsed light treatments.

Bitter PH<>.

BACKGROUND: Photodamaged skin is characterized not only by rhytides, but also by epidermal and dermal atrophy, rough skin texture, irregular pigmentation, telangiectasias, laxity, and enlarged pores. There is growing interest in the development of noninvasive methods to treat photodamaged skin. Skin photorejuvenation is the visible improvement of photodamaged skin using a laser or other light source. A noncoherent, broadband, pulsed light source is effective in the treatment of vascular and pigmented lesions of the skin. This study evaluates the role of intense pulsed light in the rejuvenation of photo aged skin. OBJECTIVE: The purpose of this study was to evaluate and quantify the degree of visible improvement in photodamaged skin following a series of full-face, intense pulsed light treatments. METHODS: Forty-nine subjects with varying degrees of photo-damage were treated with a series of four or more full-face treatments at 3-week intervals using a nonablative, nonlaser intense pulsed visible light source. Fluences varied from 30 to 50 J/cm2. Subject evaluation and skin biopsies were used to assess treatment results. RESULTS: All aspects of photodamage including wrinkling, skin coarseness, irregular pigmentation, pore size, and telangiectasias showed visible improvement in more than 90% of subjects with minimal downtime and no scarring. Eighty-eight percent of subjects were satisfied with the overall results of their treatments. CONCLUSION: Treatment of photodamaged facial skin using a series of full-face treatments with intense pulsed light is a new and effective noninvasive method of skin rejuvenation with minimal risk and no patient downtime.